Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia?

Wang, Yang, He, Guang, He, Lin and McGrath, John (2011) Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia?. Schizophrenia Research, 130 1-3: 282-284. doi:10.1016/j.schres.2011.05.009


Author Wang, Yang
He, Guang
He, Lin
McGrath, John
Title Do shared mechanisms underlying cell cycle regulation and synaptic plasticity underlie the reduced incidence of cancer in schizophrenia?
Journal name Schizophrenia Research   Check publisher's open access policy
ISSN 0920-9964
1573-2509
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1016/j.schres.2011.05.009
Volume 130
Issue 1-3
Start page 282
End page 284
Total pages 3
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2012
Language eng
Abstract Evidence from epidemiology suggests that the incidence of cancer is reduced in those with schizophrenia. Clues that could explain this finding have recently emerged from neuroscience — genes that were previously thought only to be involved in cell cycle regulation have additional functions in post-mitotic neurons related to neuronal migration and synaptic plasticity. This brief communication provides a concise summary of this evidence. We propose that this convergence between epidemiology and neuroscience will provide a more tractable search space for candidate genes, and provide clues for etiopathogenesis of schizophrenia.
Keyword Schizophrenia
Cancer
Cell cycle regulation
Synaptic plasticity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Medicine Publications
 
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