Effects of a multi-component exercise program and calcium-vitamin-D-3-fortified milk on bone mineral density in older men : A randomised controlled trial

Kukuljan, S., Nowson, C. A., Bass, S. L., Sanders, K., Nicholson, G. C., Seibel, M. J., Salmon, J. and Daly, R. M. (2009) Effects of a multi-component exercise program and calcium-vitamin-D-3-fortified milk on bone mineral density in older men : A randomised controlled trial. Osteoporosis International, 20 7: 1241-1251. doi:10.1007/s00198-008-0776-y


Author Kukuljan, S.
Nowson, C. A.
Bass, S. L.
Sanders, K.
Nicholson, G. C.
Seibel, M. J.
Salmon, J.
Daly, R. M.
Title Effects of a multi-component exercise program and calcium-vitamin-D-3-fortified milk on bone mineral density in older men : A randomised controlled trial
Journal name Osteoporosis International   Check publisher's open access policy
ISSN 0937-941X
1433-2965
Publication date 2009-07
Sub-type Article (original research)
DOI 10.1007/s00198-008-0776-y
Volume 20
Issue 7
Start page 1241
End page 1251
Total pages 11
Place of publication Guildford, Surrey, England
Publisher Springer U K
Language eng
Formatted abstract
We examined the independent and combined effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density (BMD) in older men. Exercise resulted in a 1.8% net gain in femoral neck BMD, but additional calcium-vitamin D3 did not enhance the response in this group of older well-nourished men. Introduction: This 12-month randomised controlled trial assessed whether calcium-vitamin-D 3-fortified milk could enhance the effects of a multi-component exercise program on BMD in older men. Methods: Men (n=180) aged 50-79 years were randomised into: (1) exercise + fortified milk; (2) exercise; (3) fortified milk; or (4) controls. Exercise consisted of high intensity progressive resistance training with weight-bearing impact exercise. Men assigned to fortified milk consumed 400 mL/day of low fat milk providing an additional 1,000 mg/day calcium and 800 IU/day vitamin D3. Femoral neck (FN), total hip, lumbar spine and trochanter BMD and body composition (DXA), muscle strength 25-hydroxyvitamin D and parathyroid hormone (PTH) were assessed. Results: There were no exercise-by-fortified milk interactions at any skeletal site. Exercise resulted in a 1.8% net gain in FN BMD relative to no-exercise (p<0.001); lean mass (0.6 kg, p<0.05) and muscle strength (20-52%, p<0.001) also increased in response to exercise. For lumbar spine BMD, there was a net 1.4-1.5% increase in all treatment groups relative to controls (all p<0.01). There were no main effects of fortified milk at any skeletal site. Conclusion: A multi-component community-based exercise program was effective for increasing FN BMD in older men, but additional calcium-vitamin D3 did not enhance the osteogenic response. © 2008 International Osteoporosis Foundation and National Osteoporosis Foundation.
Keyword Bmd
Calcium
Exercise
Fortified milk
Men
Vitamin D-3
High-Impact Exercise
Calcium Supplementation
Postmenopausal Women
Physical-Activity
Elderly-Women
Osteoporotic Fractures
Premenopausal Women
Proximal Femur
Risk-Factors
Double-Blind
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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