Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

Strickland, D. H., Judd, S., Thomas, J. A., Larcombe, A. N., Sly, P. D. and Holt, P. G. (2011) Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control. Mucosal Immunology, 4 1: 43-52. doi:10.1038/mi.2010.43

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Author Strickland, D. H.
Judd, S.
Thomas, J. A.
Larcombe, A. N.
Sly, P. D.
Holt, P. G.
Title Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control
Journal name Mucosal Immunology   Check publisher's open access policy
ISSN 1933-0219
Publication date 2011-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/mi.2010.43
Volume 4
Issue 1
Start page 43
End page 52
Total pages 10
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2012
Language eng
Abstract The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. This is preceded by upregulation of CD86 on resident airway dendritic cells (DCs) that normally lack competence in T-cell triggering. Moreover, AHR duration is controlled via T-regulatory (Treg) cells, which can attenuate CD86 upregulation on DC. We show that airway mucosal Treg/DC interaction represents an accessible therapeutic target for asthma control. Notably, baseline airway Treg activity in sensitized rats can be boosted by microbe-derived stimulation of the gut, resulting in enhanced capacity to control CD86 expression on airway DC triggered by aeroallergen and accelerated resolution of AHR.
Keyword Obstructive Pulmonary-Disease
Placebo-Controlled Trial
Dendritic Cells
Respiratory-Tract
Immune-Responses
Double-Blind
Bacterial Extracts
Allergic-Asthma
Atopic Disease
Lamina Propria
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 28 July 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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