Linking lung function and inflammatory responses in ventilator-induced lung injury

Cannizzaro, Vincenzo, Zoltan, Hantos, Sly, Peter D. and Zosky, Graeme R. (2011) Linking lung function and inflammatory responses in ventilator-induced lung injury. American Journal of Physiology: Lung Cellular and Molecular Physiology, 300 1: L112-L120. doi:10.1152/ajplung.00158.2010

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Author Cannizzaro, Vincenzo
Zoltan, Hantos
Sly, Peter D.
Zosky, Graeme R.
Title Linking lung function and inflammatory responses in ventilator-induced lung injury
Journal name American Journal of Physiology: Lung Cellular and Molecular Physiology   Check publisher's open access policy
ISSN 1040-0605
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1152/ajplung.00158.2010
Volume 300
Issue 1
Start page L112
End page L120
Total pages 9
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Collection year 2012
Language eng
Formatted abstract
Despite decades of research, the mechanisms of ventilator-induced lung injury are poorly understood. We used strain-dependent responses to mechanical ventilation in mice to identify associations between mechanical and inflammatory responses in the lung. BALB/c, C57BL/6, and 129/Sv mice were ventilated using a protective [low tidal volume and moderate positive end-expiratory pressure (PEEP) and recruitment maneuvers] or injurious (high tidal volume and zero PEEP) ventilation strategy. Lung mechanics and lung volume were monitored using the forced oscillation technique and plethysmography, respectively. Inflammation was assessed by measuring numbers of inflammatory cells, cytokine (IL-6, IL-1β, and TNF-α) levels, and protein content of the BAL. Principal components factor analysis was used to identify independent associations between lung function and inflammation. Mechanical and inflammatory responses in the lung were dependent on ventilation strategy and mouse strain. Three factors were identified linking 1) pulmonary edema, protein leak, and macrophages, 2) atelectasis, IL-6, and TNF-α, and 3) IL-1β and neutrophils, which were independent of responses in lung mechanics. This approach has allowed us to identify specific inflammatory responses that are independently associated with overstretch of the lung parenchyma and loss of lung volume. These data provide critical insight into the mechanical responses in the lung that drive local inflammation in ventilator-induced lung injury and the basis for future mechanistic studies in this field.
Keyword Forced oscillation technique
Lung volume
Ventilator-induced lung injury
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print October 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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