Emerging metabolic targets in cancer therapy

Zhao, Yuhua, Liu, Hao, Riker, Adam I., Fodstad, Oystein, Ledoux, Susan P., Wilson, Glenn L. and Tan, Ming (2011) Emerging metabolic targets in cancer therapy. Frontiers in Bioscience, 16 5: 1844-1860. doi:10.2741/3826

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Author Zhao, Yuhua
Liu, Hao
Riker, Adam I.
Fodstad, Oystein
Ledoux, Susan P.
Wilson, Glenn L.
Tan, Ming
Title Emerging metabolic targets in cancer therapy
Journal name Frontiers in Bioscience   Check publisher's open access policy
ISSN 1093-9946
Publication date 2011-01
Sub-type Article (original research)
DOI 10.2741/3826
Volume 16
Issue 5
Start page 1844
End page 1860
Total pages 17
Place of publication Albertson, NY, United States
Publisher Frontiers in Bioscience
Collection year 2012
Language eng
Abstract Cancer cells are different from normal cells in their metabolic properties. Normal cells mostly rely on mitochondrial oxidative phosphorylation to produce energy. In contrast, cancer cells depend mostly on glycolysis, the aerobic breakdown of glucose into ATP. This altered energy dependency is known as the "Warburg effect" and is a hallmark of cancer cells. In recent years, investigating the metabolic changes within cancer cells has been a rapidly growing area. Emerging evidence shows that oncogenes that drive the cancer-promoting signals also drive the altered metabolism. Although the exact mechanisms underlying the Warburg effect are unclear, the existing evidence suggests that increased glycolysis plays an important role in support malignant behavior of cancer cells. A thorough understanding of the unique metabolism of cancer cells will help to design of more effective drugs targeting metabolic pathways, which will greatly impact the capacity to effectively treat cancer patients. Here we provide an overview of the current understanding of the Warburg effect upon tumor cell growth and survival, and discussion on the potential metabolic targets for cancer therapy.
Keyword Cancer Therapy
Warburg Effect
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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