Corticosteroid therapy in an alphaviral arthritis

Mylonas, Andrea D., Harley, David, Purdie, David M., Pandeya, Nirmala, Vecchio, Philip C., Farmer, J. F. and Suhrbier, Andreas (2004) Corticosteroid therapy in an alphaviral arthritis. Journal of Clinical Rheumatology, 10 6: 326-330. doi:10.1097/01.rhu.0000147052.11190.36

Author Mylonas, Andrea D.
Harley, David
Purdie, David M.
Pandeya, Nirmala
Vecchio, Philip C.
Farmer, J. F.
Suhrbier, Andreas
Title Corticosteroid therapy in an alphaviral arthritis
Journal name Journal of Clinical Rheumatology   Check publisher's open access policy
ISSN 1076-1608
Publication date 2004-12
Sub-type Article (original research)
DOI 10.1097/01.rhu.0000147052.11190.36
Volume 10
Issue 6
Start page 326
End page 330
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Background: Corticosteroid use during acute viral arthritis is considered to be contraindicated as a result of the risk of immunosuppression causing enhanced infection and disease exacerbation.

Objectives: The objective of this study was to analyze the effect of oral corticosteroid therapy on symptoms of the viral arthritic disease, Ross River virus disease (RRVD).

Methods: Patients with RRVD were enrolled in 2 prospective longitudinal studies. Medications and comorbidities were recorded and the patients' health was assessed using 2 validated quality-of life-questionnaires, the Comparison of Clinical Health Assessment Questionnaire (CLINHAQ) and the Medical Outcomes Study Short Form (SF-36). Results: Six patients taking corticosteroids showed no exacerbation of RRVD compared with patients not taking steroids. The CLINHAQ Functional Disability Index also indicated that corticosteroid users recovered faster compared with patients using nonsteroidal antiinflammatory drugs.

Conclusion: Conventional concern that corticosteroid treatment will exacerbate disease appears unjustified for alphaviral arthritides once serodiagnosis has demonstrated antiviral immunity.
Keyword Alphavirus
Ross River virus
Viral arthritis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
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