Automatic MRI atlas-based external beam radiation therapy treatment planning for prostate cancer

Dowling, Jason, Lambert, Jonathan, Parker, Joel, Greer, Peter B., Fripp, Jurgen, Denham, James, Ourselin, Sebastien and Salvado, Olivier (2010). Automatic MRI atlas-based external beam radiation therapy treatment planning for prostate cancer. In: Anant Madabhushi, Jason Dowling, PingkunYan, Aaron Fenster, Purang Abolmaesumi and Nobuhiko Hata, Prostate Cancer Imaging: Computer-Aided Diagnosis, Prognosis, and Intervention International Workshop proceedings. International Workshop on Prostate Cancer Imaging: Computer-Aided Diagnosis, Prognosis, and Intervention Held in Conjunction with MICCAI 2010, Beijing, China, (25-33). 22-24 September 2010. doi:10.1007/978-3-642-15989-3_4


Author Dowling, Jason
Lambert, Jonathan
Parker, Joel
Greer, Peter B.
Fripp, Jurgen
Denham, James
Ourselin, Sebastien
Salvado, Olivier
Title of paper Automatic MRI atlas-based external beam radiation therapy treatment planning for prostate cancer
Conference name International Workshop on Prostate Cancer Imaging: Computer-Aided Diagnosis, Prognosis, and Intervention Held in Conjunction with MICCAI 2010
Conference location Beijing, China
Conference dates 22-24 September 2010
Proceedings title Prostate Cancer Imaging: Computer-Aided Diagnosis, Prognosis, and Intervention International Workshop proceedings   Check publisher's open access policy
Journal name Lecture Notes in Computer Science   Check publisher's open access policy
Place of Publication Heidelberg, Germany
Publisher Springer
Publication Year 2010
Sub-type Fully published paper
DOI 10.1007/978-3-642-15989-3_4
ISBN 9783642159886
3642159885
ISSN 0302-9743
1611-3349
Editor Anant Madabhushi
Jason Dowling
PingkunYan
Aaron Fenster
Purang Abolmaesumi
Nobuhiko Hata
Volume 6367
Start page 25
End page 33
Total pages 9
Language eng
Abstract/Summary Prostate radiation therapy dose planning currently requires computed tomography (CT) scans as they contain electron density information needed for patient dose calculations. However magnetic resonance imaging (MRI) images have significantly superior soft-tissue contrast for segmenting organs of interest and determining the target volume for treatment. This paper describes work on the development of an alternative treatment workflow enabling both organ delineation and dose planning to be performed using MRI alone. This is achieved by atlas based segmentation and the generation of pseudo-CT scans from MRI. Planning and dosimetry results for three prostate cancer patients from Calvary Mater Newcastle Hospital (Australia) are presented supporting the feasibility of this workflow. Good DSC scores were found for the atlas based segmentation of the prostate (mean 0.84) and bones (mean 0.89). The agreement between MRI/pseudo-CT and CT planning was quantified by dose differences and distance to agreement in corresponding voxels. Dose differences were found to be less than 2%. Chi values indicate that the planning CT and pseudo-CT dose distributions are equivalent.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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