Allograft loss in renal transplant recipients with Cryptococcus Neoformans associated immune reconstitution syndrome

Singh, Nina, Lortholary, Olivier, Alexander, Barbara D., Gupta, Krishan L., John, George T., Pursell, Kenneth, Munoz, Patricia, Klintmalm, Goran B., Stosor, Valentina, DelBusto, Ramon, Limaye, Ajit P., Somani, Jyoti, Lyon, Marshall, Houston, Sally, House, Andrew A., Pruett, Timothy L., Orloff, Susan, Humar, Atul, Dowdy, Lorraine, Garcia-Diaz, Julia, Fisher, Robert A., Husain, Shahid and Cryptococcal Collaborative Transplant Study Group (2005) Allograft loss in renal transplant recipients with Cryptococcus Neoformans associated immune reconstitution syndrome. Transplantation, 80 8: 1131-1133. doi:10.1097/01.tp.0000180530.17683.02


Author Singh, Nina
Lortholary, Olivier
Alexander, Barbara D.
Gupta, Krishan L.
John, George T.
Pursell, Kenneth
Munoz, Patricia
Klintmalm, Goran B.
Stosor, Valentina
DelBusto, Ramon
Limaye, Ajit P.
Somani, Jyoti
Lyon, Marshall
Houston, Sally
House, Andrew A.
Pruett, Timothy L.
Orloff, Susan
Humar, Atul
Dowdy, Lorraine
Garcia-Diaz, Julia
Fisher, Robert A.
Husain, Shahid
Cryptococcal Collaborative Transplant Study Group
Title Allograft loss in renal transplant recipients with Cryptococcus Neoformans associated immune reconstitution syndrome
Journal name Transplantation   Check publisher's open access policy
ISSN 0041-1337
Publication date 2005-10-01
Sub-type Article (original research)
DOI 10.1097/01.tp.0000180530.17683.02
Volume 80
Issue 8
Start page 1131
End page 1133
Total pages 3
Place of publication United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract This study describes the association of allograft loss and immune reconstitution syndrome (1RS) in the course of Cryptococcosis neoformans infection in renal transplant recipients. Patients comprised 54 renal allograft recipients with cryptococcosis in a prospective, multicenter study. IRS developed in 5.5% (3/54) of the renal transplant recipient with C. neoformans infection. The renal allograft was lost to chronic rejection in 66% (2/3) of the patients with cryptococcosis who developed IRS compared to 5.9% (3/51) of those who did not (P=0.012). Kaplan-Meier survival analysis showed that subsequent to cryptococcal infection the probability of allograft survival was significantly lower in patients who developed 1RS compared to those who did not develop IRS (P=0.0004). Temporal association of graft loss with IRS suggests a common pathophysiologic basis for these entities with implications relevant for the optimal management of renal transplant recipients with cryptococcosis.
Keyword Fungal infection
Cryptococcus
Transplants
Inflammatory Syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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