Intracellular compartmentalization of potassium

Adam, W. R. and Craik, D. (1989) Intracellular compartmentalization of potassium. American Journal of Kidney Diseases, 14 4: 277-280.

Author Adam, W. R.
Craik, D.
Title Intracellular compartmentalization of potassium
Journal name American Journal of Kidney Diseases   Check publisher's open access policy
ISSN 0272-6386
1523-6838
Publication date 1989-10
Sub-type Article (original research)
Volume 14
Issue 4
Start page 277
End page 280
Total pages 4
Place of publication Maryland Heights, MO, United States
Publisher W. B. Saunders
Language eng
Formatted abstract
The evidence that there is intracellular compartmentalization of potassium is indirect but diverse. Intracellular electrode measurement of potassium activity, 42K radioisotope studies, and more recently 39K nuclear magnetic resonance (NMR) all support such compartmentalization. The use of rubidium to apparently shift potassium between sites with different NMR characteristics (visibility) is strong evidence for such compartmentalization. The evidence that intracellular compartmentalization of potassium is of (patho)physiological significance is also indirect. Postulated roles for regulation of intracellular K+ activity, perhaps by control of compartmentalization, include enzyme activity, protein synthesis, and cell growth. There is also evidence that compartmentalization of potassium may contribute to the maintenance of a stable intracellular environment following potassium loading. The apparent magnetic field dependence of the visibility of K+ by 39K NMR offers the opportunity to explore further the phenomenon of compartmentalization.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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