The effect of ventricular assist devices on cerebral blood flow and blood pressure fractality

Bellapart, Judith, Chan, Gregory S. H., Tzeng, Yu-Chieh, Ainslie, Philip N., Dunster, Kimble R., Barnett, Adrian G., Boots, Rob and Fraser, John F. (2011) The effect of ventricular assist devices on cerebral blood flow and blood pressure fractality. Physiological Measurement, 32 9: 1361-1372. doi:10.1088/0967-3334/32/9/001

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Boots_Robert_authaffil.pdf Boots_Robert_authaffil.pdf application/pdf 109.35KB 0
Boots_Robert_staffdata.pdf Boots_Robert_staffdata.pdf application/pdf 70.00KB 0

Author Bellapart, Judith
Chan, Gregory S. H.
Tzeng, Yu-Chieh
Ainslie, Philip N.
Dunster, Kimble R.
Barnett, Adrian G.
Boots, Rob
Fraser, John F.
Title The effect of ventricular assist devices on cerebral blood flow and blood pressure fractality
Journal name Physiological Measurement   Check publisher's open access policy
ISSN 0967-3334
Publication date 2011-07-20
Sub-type Article (original research)
DOI 10.1088/0967-3334/32/9/001
Volume 32
Issue 9
Start page 1361
End page 1372
Total pages 12
Place of publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Collection year 2012
Language eng
Formatted abstract
Biological signals often exhibit self-similar or fractal scaling characteristics which may reflect intrinsic adaptability to their underlying physiological system. This study analysed fractal dynamics of cerebral blood flow in patients supportedwith ventricular assist devices (VAD) to ascertain if sustained modifications of blood pressure waveform affect cerebral blood flow fractality. Simultaneous recordings of arterial blood pressure and cerebral blood flow velocity using transcranial Doppler were obtained from five cardiogenic shock patients supported by VAD, five matched control patients and five healthy subjects. Computation of a fractal scaling exponent (α) at the low-frequency time scale by detrended fluctuation analysis showed that cerebral blood flow velocity exhibited 1/f fractal scaling in both patient groups (α = 0.95 ± 0.09 and 0.97 ± 0.12, respectively) as well as in the healthy subjects (α = 0.86 ±0.07). In contrast, fluctuation in blood pressure was similar to non-fractal white noise in both patient groups (α = 0.53 ± 0.11 and 0.52 ± 0.09, respectively) but exhibited 1/f scaling in the healthy subjects (α = 0.87 ± 0.04, P < 0.05 compared with the patient groups). The preservation of fractality in cerebral blood flow of VAD patients suggests that normal cardiac pulsation and central perfusion pressure changes are not the integral sources of cerebral blood flow fractality and that intrinsic vascular properties such as cerebral autoregulation may be involved. However, there is a clear difference in the fractal scaling properties of arterial blood pressure between the cardiogenic shock patients and the healthy subjects.
Keyword Blood pressure waveform variability
Cerebral blood flow irregularities
Cardiovascular instability
Fractal analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 09 Sep 2011, 15:48:24 EST by Sia Athanasas on behalf of Anaesthesiology and Critical Care - RBWH