Detection of Pulmonary Emboli With 99mTc-Labeled Anti-D-dimer (DI-80B3)Fab' Fragments (ThromboView)

Morris, Timothy A., Gerometta, Michael, Yusen, Roger D., White, Richard H., Douketis, James D., Kaatz, Scott, Smart, Richard C., Macfarlane, David and Ginsberg, Jeffrey S. (2011) Detection of Pulmonary Emboli With 99mTc-Labeled Anti-D-dimer (DI-80B3)Fab' Fragments (ThromboView). American Journal of Respiratory and Critical Care Medicine, 184 6: 708-714. doi:10.1164/rccm.201104-0624OC

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
Macfarlane_authoraffil.pdf Macfarlane_authoraffil.pdf application/pdf 58.77KB 1
Mafarlane_authoraffil_staffdata.pdf Mafarlane_authoraffil_staffdata.pdf application/pdf 53.16KB 1

Author Morris, Timothy A.
Gerometta, Michael
Yusen, Roger D.
White, Richard H.
Douketis, James D.
Kaatz, Scott
Smart, Richard C.
Macfarlane, David
Ginsberg, Jeffrey S.
Title Detection of Pulmonary Emboli With 99mTc-Labeled Anti-D-dimer (DI-80B3)Fab' Fragments (ThromboView)
Formatted title
Detection of Pulmonary Emboli With 99mTc-Labeled Anti-D-dimer (DI-80B3)Fab' Fragments (ThromboView)
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1535-4970
1073-449X
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1164/rccm.201104-0624OC
Volume 184
Issue 6
Start page 708
End page 714
Total pages 7
Place of publication New York, NY, United States
Publisher American Thoracic Society
Collection year 2012
Language eng
Formatted abstract
Rationale: We report a new method to diagnose acute pulmonary embolism by
single photon emission computerized tomography (SPECT) after administration of
99mTc-labeled anti-D-dimer (DI-80B3) monoclonal antibody Fab’ fragments. This
novel technique provides an additional approach to diagnosing pulmonary
embolism in patients for whom other methods are non-diagnostic or
contraindicated.
Objectives: We performed a prospective, multicenter study to investigate the
sensitivity and specificity of 99mTc-DI-80B3/SPECT in patients with suspected acute
pulmonary embolism.
Methods: Subjects with a moderate to high clinical probability of pulmonary
embolism or a positive D-dimer test underwent a PE-protocol contrast-enhanced
multidetector thoracic CT as well as 99mTc-DI-80B3/SPECT (0.5 mg 99mTc-DI-80B3
intravenously followed by a thoracic SPECT 2.5 hours later). Separate and
independent adjudication committees, blinded to clinical data and other test results,
interpreted the 99mTc-DI-80B3/SPECT scans (pulmonary embolism detected as foci
of abnormally increased 99mTc uptake) and the thoracic CT scans using PIOPED II
criteria.
Results: Of the 52 patients who were enrolled and completed both tests, 42 had
both evaluable SPECT scans and thoracic CT scans. Using the criterion standard
(thoracic CT) there were 21 patients with pulmonary embolism and 21 without.
99mTc-DI-80B3/SPECT had a sensitivity of 76.2% (95% CI 52.8% to 91.8%) and a
specificity of 90.5% (95% CI 69.8% to 98.8%). Treatment-related serious adverse
events did not occur.
Conclusions: 99mTc-DI-80B3/SPECT was sensitive and specific for acute pulmonary
embolism in subjects with moderate to high clinical probability of pulmonary
embolism or a positive D-dimer test. 99mTc-DI-80B3/SPECT demonstrated an
acceptable safety profile and avoids exposure to contrast.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Jun 16. [Epub ahead of print]

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 07 Sep 2011, 10:25:50 EST by Matthew Lamb on behalf of School of Medicine