Appraisals of stressful life events as a genetically-linked mechanism in the stress-depression relationship

Conway, Christopher C., Hammen, Constance, Espejo, Emmanuel P., Wray, Naomi R., Najman, Jake M. and Brennan, Patricia A. (2012) Appraisals of stressful life events as a genetically-linked mechanism in the stress-depression relationship. Cognitive Therapy and Research, 36 4: 338-347. doi:10.1007/s10608-011-9368-9


Author Conway, Christopher C.
Hammen, Constance
Espejo, Emmanuel P.
Wray, Naomi R.
Najman, Jake M.
Brennan, Patricia A.
Title Appraisals of stressful life events as a genetically-linked mechanism in the stress-depression relationship
Journal name Cognitive Therapy and Research   Check publisher's open access policy
ISSN 0147-5916
1573-2819
Publication date 2012-08
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s10608-011-9368-9
Volume 36
Issue 4
Start page 338
End page 347
Total pages 10
Place of publication New York, NY, United States
Publisher Springer New York
Collection year 2012
Language eng
Abstract Variation in the promoter region of the serotonin transporter gene (5-HTTLPR) has been linked to various cognitive-affective indices of stress sensitivity hypothesized to underlie vulnerability to depression. The current study examined the association of 5-HTTLPR with appraisals of naturally occurring acute life stressors in a community sample of 384 youth at elevated risk for depression due to oversampling for maternal depression. Interview measures administered at youth age 20 were used to assess subjective and objective (assigned by an independent rating team) appraisals of the negative impact of recent acute stressful life events. The presence of at least one S allele was associated with elevated subjective appraisals of the negative impact of acute stressors (P = 0.03). Consistent with an endophenotype perspective, support was found for a 5-HTTLPR-stress appraisals-depression mediation model both concurrently and longitudinally. Results indicate that enhanced stress sensitivity may act as an intermediate phenotype through which 5-HTTLPR affects risk for depression.
Keyword Depression
Endophenotype
Serotonin transporter gene
Stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 10 May 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
 
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Created: Tue, 06 Sep 2011, 15:22:36 EST by Geraldine Fitzgerald on behalf of School of Public Health