Adiponectin receptor signalling in the brain

Thundyil, John, Pavlovski, Dale, Sobey, Christopher G. and Arumugam, Thiruma V. (2012) Adiponectin receptor signalling in the brain. British Journal of Pharmacology, 165 2: 313-327.


Author Thundyil, John
Pavlovski, Dale
Sobey, Christopher G.
Arumugam, Thiruma V.
Title Adiponectin receptor signalling in the brain
Journal name British Journal of Pharmacology   Check publisher's open access policy
ISSN 0007-1188
1476-5381
Publication date 2012-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1476-5381.2011.01560.x
Volume 165
Issue 2
Start page 313
End page 327
Total pages 15
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2013
Language eng
Abstract Adiponectin is an important adipocyte-derived hormone that regulates metabolism of lipids and glucose, and its receptors (AdipoR1, AdipoR2, T-cadherin) appear to exert actions in peripheral tissues by activating the AMP-activated protein kinase, p38 mitogen-activated protein kinase, peroxisome proliferator activated receptor α and nuclear factor-kappa B. Adiponectin has been shown to exert a wide range of biological functions that could elicit different effects, depending on the target organ and the biological mileu. There is substantial evidence to suggest that adiponectin receptors are expressed widely in the brain. Their expression has been detected in regions of the mouse hypothalamus, brainstem, cortical neurons and endothelial cells, as well as in whole brain and pituitary extracts. While there is now considerable evidence for the presence of adiponectin and its receptors in the brain, their precise roles in brain diseases still remain unclear. Only a few research studies have looked at this facet of adiponectins in brain disorders. This brief review will describe the evidence for important functions by adiponectin, its structure and known actions, evidence for expression of AdipoRs in the brain, their involvement in brain disorders, and the therapeutic potential of agents that could modify AdipoR signalling.
Keyword Adiponectin
Adiponectin receptors
Alzheimer’s disease
Brain diseases
Cell death
Ischemic stroke
Multiple sclerosis
Neuronal cells
NF-κB
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 16 DEC 2011

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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Created: Tue, 06 Sep 2011, 08:58:18 EST by Dr Thiruma V Arumugam on behalf of School of Biomedical Sciences