Signalling pathways and the host-parasite relationship: Putative targets for control interventions against schistosomiasis Signalling pathways and future anti-schistosome therapies

You, Hong, Gobert, Geoffrey N., Jones, Malcolm K., Zhang, Wenbao and McManus, Donald P. (2011) Signalling pathways and the host-parasite relationship: Putative targets for control interventions against schistosomiasis Signalling pathways and future anti-schistosome therapies. Bioessays, 33 3: 203-214. doi:10.1002/bies.201000077


Author You, Hong
Gobert, Geoffrey N.
Jones, Malcolm K.
Zhang, Wenbao
McManus, Donald P.
Title Signalling pathways and the host-parasite relationship: Putative targets for control interventions against schistosomiasis Signalling pathways and future anti-schistosome therapies
Journal name Bioessays   Check publisher's open access policy
ISSN 0265-9247
1521-1878
Publication date 2011-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/bies.201000077
Volume 33
Issue 3
Start page 203
End page 214
Total pages 12
Place of publication Bognor Regis, United Kingdom
Publisher John Wiley and Sons
Collection year 2012
Language eng
Abstract A better understanding of how schistosomes exploit host nutrients, neuro-endocrine hormones and signalling pathways for growth, development and maturation may provide new insights for improved interventions in the control of schistosomiasis. This paper describes recent advances in the identification and characterisation of schistosome tyrosine kinase and signalling pathways. It discusses the potential intervention value of insulin signalling, which may play an important role in glucose uptake and carbohydrate metabolism in schistosomes, providing the nutrients essential for parasite growth, development and, notably, female fecundity. Significant progress has also been made in the characterisation of other schistosome growth factor receptors, such as transforming growth factor beta receptor and epidermal growth factor receptor, and in our understanding of their roles in the host-parasite molecular dialogue and parasite development. The use of parasite signal transduction components as novel vaccine or drug targets may prove invaluable in prevention, treatment and control strategies to combat schistosomiasis.
Keyword host-parasite interaction
insulin receptor
schistosome
schistosomiasis
signalling pathway
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Public Health Publications
School of Veterinary Science Publications
 
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