Selective atrophy of left hemisphere and frontal lobe of the brain in old men

Shan, Zu Y., Liu, Jing Z., Sahgal, Vinod, Wang, Bin and Yue, Guang H. (2005) Selective atrophy of left hemisphere and frontal lobe of the brain in old men. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 60 2: 165-174. doi:10.1093/gerona/60.2.165


Author Shan, Zu Y.
Liu, Jing Z.
Sahgal, Vinod
Wang, Bin
Yue, Guang H.
Title Selective atrophy of left hemisphere and frontal lobe of the brain in old men
Journal name Journals of Gerontology Series A: Biological Sciences and Medical Sciences   Check publisher's open access policy
ISSN 1079-5006
1758-535X
Publication date 2005-02
Sub-type Article (original research)
DOI 10.1093/gerona/60.2.165
Volume 60
Issue 2
Start page 165
End page 174
Total pages 10
Place of publication Cary, NC, United States
Publisher Oxford University Press
Language eng
Abstract In this study, volumes of the whole brain, hemispheres, and frontal lobes of young and elderly adults were quantified by an automated method. Effects of age, sex, and side on absolute and relative volumes of the brain structures were evaluated. Compared with the young group, elderly participants showed a 15% volume loss in the whole brain and hemispheres, and a 22% volume loss in the frontal lobes. The relative volume of the left hemisphere in the elderly group decreased more than that of the right hemisphere. Elderly men showed significantly greater left hemisphere and left frontal lobe volume losses than did elderly women, indicating that the larger left hemisphere relative volume reduction is largely contributed to by selective atrophy of the left frontal lobe volume in elderly men. These results may reflect age- and sex-related functional deterioration in the left brain.
Keyword Positron-emission-tomography
Age-related differences
Observed in-vivo
Magnetic-resonance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Centre for Advanced Imaging Publications
 
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