Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia

Reddick, Wilburn E., Shan, Zuyao Y., Glass, John O., Helton, Susan, Xiong, Xiaoping, Wu, Shengjie, Banner, Melanie J., Howard, Scott C., Christensen, Robbin, Khan, Raja B., Pui, Ching-Hon and Mulhern, Raymond K. (2006) Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia. Cancer, 106 4: 941-949. doi:10.1002/cncr.21679


Author Reddick, Wilburn E.
Shan, Zuyao Y.
Glass, John O.
Helton, Susan
Xiong, Xiaoping
Wu, Shengjie
Banner, Melanie J.
Howard, Scott C.
Christensen, Robbin
Khan, Raja B.
Pui, Ching-Hon
Mulhern, Raymond K.
Title Smaller white-matter volumes are associated with larger deficits in attention and learning among long-term survivors of acute lymphoblastic leukemia
Journal name Cancer   Check publisher's open access policy
ISSN 0008-543X
1097-0142
Publication date 2006-02
Sub-type Article (original research)
DOI 10.1002/cncr.21679
Volume 106
Issue 4
Start page 941
End page 949
Total pages 9
Place of publication Hoboken, NJ United States
Publisher John Wiley & Sons, Inc.
Language eng
Formatted abstract
BACKGROUND. The primary objective of this study was to test the hypothesis that survivors of childhood acute lymphoblastic leukemia (ALL) have deficits in neurocognitive performance, and smaller white-matter volumes are associated with these deficits. METHODS. The patients studied included 112 ALL survivors (84 patients who had received chemotherapy only, 28 patients who had received chemotherapy and irradiation; 63 males, 49 females; mean age ± standard deviation, 4.1 yrs ± 2.6 yrs at diagnosis; mean ± standard deviation yrs since diagnosis, 6.0 ± 3.5 yrs), and 33 healthy siblings who participated as a control group. Neurocognitive tests of attention, intelligence, and academic achievement were performed; and magnetic resonance images were obtained and subsequently were segmented to yield tissue volume measurements. Comparisons of neurocognitive measures and tissue volumes between groups were performed, and the correlations between volumes and neurocognitive performance measures were assessed. RESULTS. Most performance measures demonstrated statistically significant differences from the normative test scores, but only attention measures exceeded 1.0 standard deviation from normal. Patients who had received chemotherapy alone had significantly larger volumes of white matter than patients who had received treatment that also included cranial irradiation, but their volumes remained significantly smaller than the volumes in the control group. Smaller white-matter volumes were associated significantly with larger deficits in attention, intelligence, and academic achievement. CONCLUSIONS. Survivors of childhood ALL had significant deficits in attention and smaller white-matter volumes that were associated directly with impaired neurocognitive performance. Cranial irradiation exacerbated these deficits. © 2006 American Cancer Society.
Keyword Acute lymphoblastic leukemia
Magnetic resonance imaging
Image analysis
Neuropsychology
Neurotoxicity
Attention
Neurocognitive Deficits
Developmental Model
Radiation-Therapy
Children
Brain
Chemotherapy
Irradiation
Segmentation
Methotrexate
Iron
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
Centre for Advanced Imaging Publications
 
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