Papillary tumour of the pineal region

Poulgrain, Katherine, Gurgo, Ross, Winter, Craig, Ong, Benjamin and Lau, Queenie (2011) Papillary tumour of the pineal region. Journal of Clinical Neuroscience, 18 8: 1007-1017. doi:10.1016/j.jocn.2010.12.027

Author Poulgrain, Katherine
Gurgo, Ross
Winter, Craig
Ong, Benjamin
Lau, Queenie
Title Papillary tumour of the pineal region
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
Publication date 2011-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jocn.2010.12.027
Volume 18
Issue 8
Start page 1007
End page 1017
Total pages 11
Place of publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Collection year 2012
Language eng
Abstract Papillary tumour of the pineal region (PTRR) is one of the new tumour entities to be included in the latest World Health Organization classification of central nervous system tumours. We report two illustrative patients, a 25-year-old female who presented following a head injury sustained from a fall due to gait disturbances, and a 42-year-old man who presented with headaches. Histology of both cases showed distinct papillary growth patterns with lining of the papillae by multi-layered cuboidal to columnar cells, prominent perivascular rosette and focal true rosette formation. Immunohistochemistry exhibited strong cytokeratin immunoreactivity in addition to CD56, focal S100, glial fibrillary acidic protein and neuron specific enolase positivity which supported a diagnosis of PTPR in both patients. Postoperatively, both patients underwent courses of adjuvant radiation therapy. One patient reported local recurrence of the tumour 23 months after surgery. While PTPR may have been misdiagnosed in the past, clear and consistent characteristics are beginning to be elucidated in the published reports and literature, which have been reviewed. As a relatively new distinct clinicopathological entity, prognostic data are limited and guidelines for treatment protocols are still being investigated in view of its propensity for local recurrence.
Keyword Papillary neoplasm
Papillary tumour of the pineal region
Pineal region
Pineal tumour
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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