Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro

Shing, Cecilia M., Adams, Murray J., Fassett, Robert G. and Coombes, Jeff S. (2011) Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro. Nutrition, 27 9: 967-972. doi:10.1016/j.nut.2010.10.014


Author Shing, Cecilia M.
Adams, Murray J.
Fassett, Robert G.
Coombes, Jeff S.
Title Nutritional compounds influence tissue factor expression and inflammation of chronic kidney disease patients in vitro
Journal name Nutrition   Check publisher's open access policy
ISSN 0899-9007
1873-1244
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1016/j.nut.2010.10.014
Volume 27
Issue 9
Start page 967
End page 972
Total pages 6
Place of publication New York, NY, United States
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Objective: Nutritional compounds that potentially limit inflammation and tissue factor expression may decrease the progression of chronic kidney disease (CKD) and associated cardiovascular disease. This project aimed to determine the effect of curcumin, bovine colostrum, and fish oil on inflammatory cytokine and tissue factor procoagulant activity of peripheral blood mononuclear cells (PBMCs) from patients with CKD before dialysis.

Methods: Peripheral blood mononuclear cells from patients with CKD before dialysis (n = 13) and age- and sex-matched healthy controls (n = 12) were cultured alone and with low and high doses of the nutritional compounds for 24 h. Cells were cultured with and without lipopolysaccharide. Supernatants were analyzed for tumor necrosis factor-α, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1, IL-1β, C-reactive protein, and tissue factor procoagulant activity.

Results: The production of C-reactive protein, monocyte chemoattractant protein-1, IL-6, and IL-1β by PBMCs was inhibited by low- and high-dose fish oil in the CKD group (P < 0.05). Curcumin decreased secretion of IL-6 (P = 0.015) and IL-1 β (P = 0.016). Curcumin was more effective than colostrum at decreasing the procoagulant activity of PBMCs in the CKD and control groups (P < 0.019).

Conclusion: Fish oil decreased inflammatory cytokine secretion from CKD PBMCs. In addition, the beneficial effects of curcumin were demonstrated in decreasing inflammation in vitro, often to a similar magnitude as fish oil.
Keyword Fish oil
Colostrum, curcumin
Kidney disease
Cytokines
Procoagulant activity
Blood mononuclear-cells
C-reactive protein
Factor-kappa-B
Bovine colostrum supplementation
Chronic-renal-failure
N-3 fatty-acids
Cytokine production
Adhesion molecules
Curcumin
Activation
Factor-κB
NF-κB
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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