The anti-oxidant action of carvedilol protects the kidney from cisplatin-induced nephrotoxicity but does not reduce the chemotherapeutic value of cisplatin

Carvalho Rodrigues, M. A., Faria, M. C. S., Rodrigues, J. L., Santos, N. A. G., Barbosa Jr., F., Gobe, G. and Santos, A. C. (2011). The anti-oxidant action of carvedilol protects the kidney from cisplatin-induced nephrotoxicity but does not reduce the chemotherapeutic value of cisplatin. In: Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX). EUROTOX Paris 2011: 47th Congress of the European Societies of Toxicology, Porte Maillot, Paris, France, (S271-S271). 28-31 August 2011. doi:10.1016/j.toxlet.2011.05.920


Author Carvalho Rodrigues, M. A.
Faria, M. C. S.
Rodrigues, J. L.
Santos, N. A. G.
Barbosa Jr., F.
Gobe, G.
Santos, A. C.
Title of paper The anti-oxidant action of carvedilol protects the kidney from cisplatin-induced nephrotoxicity but does not reduce the chemotherapeutic value of cisplatin
Conference name EUROTOX Paris 2011: 47th Congress of the European Societies of Toxicology
Conference location Porte Maillot, Paris, France
Conference dates 28-31 August 2011
Proceedings title Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX)   Check publisher's open access policy
Journal name Toxicology Letters   Check publisher's open access policy
Place of Publication E. Park, Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Publication Year 2011
Sub-type Published abstract
DOI 10.1016/j.toxlet.2011.05.920
ISSN 0378-4274
Volume 205
Issue Supp. 1
Start page S271
End page S271
Total pages 1
Language eng
Formatted Abstract/Summary
Purpose: The chemotherapeutic agent cisplatin (CISP) is widely used, but its inherent nephrotoxicity limits its potential. Nephrotoxicity is caused in part via oxidative stress-induced apoptosis. This study aimed to evaluate the renoprotective effect of carvedilol (CV), known to have strong antioxidant action, as well as any interference CV may have with the chemotherapeutic action of CISP.

In summary, CV may be a useful adjuvant treatment to reduce CISP-induced nephrotoxicity while not affecting its tumor toxicity.
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under "Poster Session 2" as Poster Abstract #P2296.

Document type: Conference Paper
Collections: Non HERDC
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