Indoor residual spray and insecticide-treated bednets for malaria control: Theoretical synergisms and antagonisms

Yakob, Laith, Dunning, Rebecca and Yan, Guiyun (2011) Indoor residual spray and insecticide-treated bednets for malaria control: Theoretical synergisms and antagonisms. Journal of The Royal Society Interface, 8 59: 799-806. doi:10.1098/rsif.2010.0537

Author Yakob, Laith
Dunning, Rebecca
Yan, Guiyun
Title Indoor residual spray and insecticide-treated bednets for malaria control: Theoretical synergisms and antagonisms
Journal name Journal of The Royal Society Interface   Check publisher's open access policy
ISSN 1742-5662
Publication date 2011-06-06
Year available 2010
Sub-type Article (original research)
DOI 10.1098/rsif.2010.0537
Volume 8
Issue 59
Start page 799
End page 806
Total pages 8
Place of publication London, U.K.
Publisher The Royal Society Publishing
Collection year 2012
Language eng
Formatted abstract
Indoor residual spray (IRS) of insecticides and insecticide-treated bednets (ITNs) are the two most important malaria vector control tools in the tropical world. Application of both tools in the same locations is being implemented for malaria control in endemic and epidemic Africa. The two tools are assumed to have synergistic benefits in reducing malaria transmission because they both act at multiple stages of the transmission cycle. However, this assumption has not been rigorously examined, empirically or theoretically. Using mathematical modelling, we obtained the conditions for which a combination strategy can be expected to improve upon single control tools. Specifically, spraying of dichlorodiphenyltrichloroethane (DDT) in all houses where residents are not using ITNs can reduce transmission of malaria (R0) by up to 10 times more than the reduction achieved through ITNs alone. Importantly, however, we also show how antagonism between control tools can arise via interference of their modes of action. Repellent IRS reduces the likelihood that ITNs are contacted within sprayed houses and ITNs reduce the rate at which blood-fed mosquitoes rest on sprayed walls. For example, 80 per cent coverage of ITNs and DDT used together at the household level resulted in an R0 of 11.1 when compared with an R0 of 0.1 achieved with 80 per cent ITN coverage without DDT. While this undesired effect can be avoided using low-repellence pyrethroid chemicals for IRS, the extent of the potential benefits is also attenuated. We discuss the impact that this result will likely have on future efforts in malaria control combination strategy.
Keyword Integrated vector management
Transmission dynamics
Experimental hut trials
Western Kenya
Borne disease
Endemic area
Bed nets
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print November 17, 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biological Sciences Publications
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 02 Sep 2011, 10:58:43 EST by Gail Walter on behalf of School of Biological Sciences