Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery

Ziora, Zyta M., Wimmer, Norbert, New, Roger, Skwarczynski, Mariusz and Toth, Istvan (2011) Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery. Carbohydrate Research, 346 12: 1439-1444. doi:10.1016/j.carres.2011.03.019

Author Ziora, Zyta M.
Wimmer, Norbert
New, Roger
Skwarczynski, Mariusz
Toth, Istvan
Title Synthesis of glycolipopeptidic building blocks for carbohydrate receptor discovery
Journal name Carbohydrate Research   Check publisher's open access policy
ISSN 0008-6215
Publication date 2011-09-06
Sub-type Article (original research)
DOI 10.1016/j.carres.2011.03.019
Volume 346
Issue 12
Start page 1439
End page 1444
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2012
Language eng
Abstract A class of glycolipopeptides for use as building blocks for a new type of dynamic combinatorial library is reported. The members of the library consist of a variable carbohydrate moiety, coded amino acids, and lipoamino acids in order to convert them into amphiphiles. Glycolipopeptidic amphiphiles interact through non-covalent bonding when mixed together in aqueous phase and form micelles in dynamic close-packed fluid mosaic arrays. The head groups of amphiphiles are exposed on the micelle surface, providing entities which could be screened in biological assays to find the most potent combination of building blocks in order to identify new bioactive carbohydrate ligands.
Keyword Lipoamino acids
Dynamic combinatorial library
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Carbohydrates as Ligands: Synthetic and Biological Aspects. Dedicated to Professor András Lipták on the occasion of his 75th birthday

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