Pore-forming toxins induce multiple cellular responses promoting survival

Gonzalez, Manuel R., Bischofberger, Mirko, Freche, Barbara, Ho, Sylvia, Parton, Robert G. and van der Goot, F. Gisou (2011) Pore-forming toxins induce multiple cellular responses promoting survival. Cellular Microbiology, 13 7: 1026-1043. doi:10.1111/j.1462-5822.2011.01600.x


Author Gonzalez, Manuel R.
Bischofberger, Mirko
Freche, Barbara
Ho, Sylvia
Parton, Robert G.
van der Goot, F. Gisou
Title Pore-forming toxins induce multiple cellular responses promoting survival
Journal name Cellular Microbiology   Check publisher's open access policy
ISSN 1462-5814
1462-5822
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1111/j.1462-5822.2011.01600.x
Volume 13
Issue 7
Start page 1026
End page 1043
Total pages 18
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Abstract Pore-forming toxins (PFTs) are secreted proteins that contribute to the virulence of a great variety of bacterial pathogens. They inflict one of the more disastrous damages a target cell can be exposed to: disruption of plasma membrane integrity. Since this is an ancient form of attack, which bares similarities to mechanical membrane damage, cells have evolved response pathways to these perturbations. Here, it is reported that PFTs trigger very diverse yet specific response pathways. Many are triggered by the decrease in cytoplasmic potassium, which thus emerges as a central regulator. Upon plasma membrane damage, cells activate signalling pathways aimed at restoring plasma membrane integrity and ion homeostasis. Interestingly these pathways do not require protein synthesis. Cells also trigger signalling cascades that allow them to enter a quiescent-like state, where minimal energy is consumed while waiting for plasma membrane damage to be repaired. More specifically, protein synthesis is arrested, cytosolic constituents are recycled by autophagy and energy is stored in lipid droplets.
Keyword Activated protein-kinase
Cholesterol-dependent cytolysin
Staphylococcus-aureus
Alpha-toxin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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