Prevalence and determinants of Helicobacter pylori sero-positivity in the Australian adult community

Pandeya, Nirmala and Whiteman, David C. (2011) Prevalence and determinants of Helicobacter pylori sero-positivity in the Australian adult community. Journal of Gastroenterology and Hepatology, 26 8: 1283-1289. doi:10.1111/j.1440-1746.2011.06726.x


Author Pandeya, Nirmala
Whiteman, David C.
Title Prevalence and determinants of Helicobacter pylori sero-positivity in the Australian adult community
Formatted title
Prevalence and determinants of Helicobacter pylori sero-positivity in the Australian adult community
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 0815-9319
1440-1746
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1111/j.1440-1746.2011.06726.x
Volume 26
Issue 8
Start page 1283
End page 1289
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2012
Language eng
Formatted abstract
Background and Aim:  To estimate the sero-prevalence of Helicobacter Pylori infection in the Australian adult population and identify determinants.

Methods:  We analyzed serum samples and questionnaire data from 1355 community controls who participated in a nationwide case-control study of esophageal cancer in Australia between 2002 and 2005. We estimated the prevalence ratio and 95% confidence interval using log binomial regression models.

Results:  The age and sex standardized sero-prevalence of H. pylori was 15.5%. The prevalence of infection varied significantly with age, ranging from 5% (< 40 years) to 32% (≥ 70 years). H. pylori infection was significantly higher among those born overseas (prevalence ratio [PR] 1.63; 95% confidence interval [CI] 1.34–1.98) compared with those born in Australia or New Zealand. H. pylori sero-prevalence was 23% higher among participants living in the lowest quartile of socio-economic areas (PR 0.77; 95%CI 0.59–0.99 for Q4 compared with Q1). H pylori serostatus was significantly inversely associated with university education (PR 0.56; 95%CI 0.38–0.83), frequent reflux symptoms (PR 0.62; 95%CI 0.42–0.91), use of proton pump inhibitor (PR 0.69; 95%CI 0.48–0.98) and use of medications for gut spasms (PR 0.48; 95%CI 0.25–0.93). H. pylori serostatus was not associated with body mass index, smoking, alcohol or physical activity.

Conclusions: 
The prevalence of H. pylori infection in Australian adults is lower than other developed countries. H. pylori infection is most common among those living in the areas of socio-economic disadvantage or who were born overseas.
Keyword Epidemiology < gastroenterology
Helicobacter pylori < gastroenterology
Seroprevalence
Risk-factors
Gastric-cancer
Response rates
Birth cohort
Odds ratio
Infection
Population
Epidemiology
Seroprevalence
Metaanalysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Public Health Publications
 
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