Sexual dimorphism in lung function responses to acute influenza A infection

Larcombe, Alexander N., Foong, Rachel E., Bozanich, Elizabeth M., Berry, Luke J., Garratt, Luke W., Gualano, Rosa C., Jones, Jessica E., Dousha, Lovisa F., Zosky, Graeme R. and Sly, Peter D. (2011) Sexual dimorphism in lung function responses to acute influenza A infection. Influenza and Other Respiratory Viruses, 5 5: 334-342. doi:10.1111/j.1750-2659.2011.00236.x

Author Larcombe, Alexander N.
Foong, Rachel E.
Bozanich, Elizabeth M.
Berry, Luke J.
Garratt, Luke W.
Gualano, Rosa C.
Jones, Jessica E.
Dousha, Lovisa F.
Zosky, Graeme R.
Sly, Peter D.
Title Sexual dimorphism in lung function responses to acute influenza A infection
Journal name Influenza and Other Respiratory Viruses   Check publisher's open access policy
ISSN 1750-2640
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1111/j.1750-2659.2011.00236.x
Open Access Status DOI
Volume 5
Issue 5
Start page 334
End page 342
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Background  Males are generally more susceptible to respiratory infections; however, there are few data on the physiological responses to such infections in males and females.

Objectives  To determine whether sexual dimorphism exists in the physiological/inflammatory responses of weanling and adult BALB/c mice to influenza.

  Weanling and adult mice of both sexes were inoculated with influenza A or appropriate control solution. Respiratory mechanics, responsiveness to methacholine (MCh), viral titre and bronchoalveolar lavage (BAL) cellular inflammation/cytokines were measured 4 (acute) and 21 (resolution) days post-inoculation.

Results  Acute infection impaired lung function and induced hyperresponsiveness and cellular inflammation in both sexes at both ages. Males and females responded differently with female mice developing greater abnormalities in tissue damping and elastance and greater MCh responsiveness at both ages. BAL inflammation, cytokines and lung viral titres were similar between the sexes. At resolution, all parameters had returned to baseline levels in adults and weanling males; however, female weanlings had persisting hyperresponsiveness.

Conclusions  We identified significant differences in the physiological responses of male and female mice to infection with influenza A, which occurred in the absence of variation in viral titre and cellular inflammation.
Keyword Airway responsiveness
Cellular inflammation
Sexual dimorphism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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