Genome-wide association study identifies a common variant associated with risk of endometrial cancer

Spurdle, Amanda B., Thompson, Deborah J., Ahmed, Shahana, Ferguson, Kaltin, Healey, Catherine S., O'Mara, Tracy, Walker, Logan C., Montgomery, Stephen B., Dermitzakis, Emmanouil T., The Australian National Endometrial Cancer Study Group, Fahey, Paul, Montgomery, Grant W., Webb, Penelope M., Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hein, Alexander, Lambrechts, Diether, Coenegrachts, Lieve, Vergote, Ignace, Amant, Frederic, Salvesen, Helga B., Trovik, Jone, Njolstad, Tormund S., Helland, Harald, Scott, Rodney J., Ashton, Katie, Proietto, Tony, Otton, Geoffrey, National Study of Endometrial Cancer Genetics Group, Tomlinson, Ian, Gorman, Maggie, Howarth, Kimberley, Hodgson, Shirley, Garcia-Closas, Montserrat, Wentzensen, Nicolas, Yang, Hannah, Chanock, Stephen, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Jingmei, Shu, Xiao-Ou, Zheng, Wei, Long, Jirong, Xiang, Yong-Bing, Shah, Mitul, Morrison, Jonathan, Michailidou, Kyriaki, Pharoah, Paul D., Dunning, Alison M. and Easton, Douglas F. (2011) Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nature Genetics, 43 5: 451-454. doi:10.1038/ng.812

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Author Spurdle, Amanda B.
Thompson, Deborah J.
Ahmed, Shahana
Ferguson, Kaltin
Healey, Catherine S.
O'Mara, Tracy
Walker, Logan C.
Montgomery, Stephen B.
Dermitzakis, Emmanouil T.
The Australian National Endometrial Cancer Study Group
Fahey, Paul
Montgomery, Grant W.
Webb, Penelope M.
Fasching, Peter A.
Beckmann, Matthias W.
Ekici, Arif B.
Hein, Alexander
Lambrechts, Diether
Coenegrachts, Lieve
Vergote, Ignace
Amant, Frederic
Salvesen, Helga B.
Trovik, Jone
Njolstad, Tormund S.
Helland, Harald
Scott, Rodney J.
Ashton, Katie
Proietto, Tony
Otton, Geoffrey
National Study of Endometrial Cancer Genetics Group
Tomlinson, Ian
Gorman, Maggie
Howarth, Kimberley
Hodgson, Shirley
Garcia-Closas, Montserrat
Wentzensen, Nicolas
Yang, Hannah
Chanock, Stephen
Hall, Per
Czene, Kamila
Liu, Jianjun
Li, Jingmei
Shu, Xiao-Ou
Zheng, Wei
Long, Jirong
Xiang, Yong-Bing
Shah, Mitul
Morrison, Jonathan
Michailidou, Kyriaki
Pharoah, Paul D.
Dunning, Alison M.
Easton, Douglas F.
Title Genome-wide association study identifies a common variant associated with risk of endometrial cancer
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2011-05
Sub-type Article (original research)
DOI 10.1038/ng.812
Volume 43
Issue 5
Start page 451
End page 454
Total pages 4
Place of publication New York, NY, U.S.A.
Publisher Nature Publishing Group
Collection year 2012
Language eng
Formatted abstract
Endometrial cancer is the most common malignancy of the female genital tract in developed countries. To identify genetic variants associated with endometrial cancer risk, we performed a genome-wide association study involving 1,265 individuals with endometrial cancer (cases) from Australia and the UK and 5,190 controls from the Wellcome Trust Case Control Consortium. We compared genotype frequencies in cases and controls for 519,655 SNPs. Forty seven SNPs that showed evidence of association with endometrial cancer in stage 1 were genotyped in 3,957 additional cases and 6,886 controls. We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7.1 × 10−10) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 67 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 72 times in Scopus Article | Citations
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Created: Wed, 24 Aug 2011, 13:18:39 EST by Vicki Percival on behalf of School of Medicine