Aldosterone and cardiovascular disease

Gaddam, Krishna K., Pimenta, Eduardo, Husain, Saima and Calhoun, David A. (2009) Aldosterone and cardiovascular disease. Current Problems in Cardiology, 34 2: 51-84. doi:10.1016/j.cpcardiol.2008.10.002

Author Gaddam, Krishna K.
Pimenta, Eduardo
Husain, Saima
Calhoun, David A.
Title Aldosterone and cardiovascular disease
Journal name Current Problems in Cardiology   Check publisher's open access policy
ISSN 0146-2806
Publication date 2009-02
Sub-type Article (original research)
DOI 10.1016/j.cpcardiol.2008.10.002
Volume 34
Issue 2
Start page 51
End page 84
Total pages 34
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Aldosterone is an adrenal hormone that regulates sodium, fluid, and potassium balance. Jerome Conn first described the syndrome of autonomous and excessive aldosterone secretion or "primary aldosteronism." Contrary to the historical belief, recent studies indicate that primary aldosteronism is a common cause of hypertension with a prevalence of 5-10% among general hypertensive patients. Various animal models have demonstrated that aldosterone in association with a high salt diet results in target-organ inflammation and fibrosis. Similarly, cross-sectional and observational human studies have demonstrated the association of aldosterone with development and severity of hypertension, congestive heart failure, coronary artery disease, chronic kidney disease, and metabolic syndrome. Several interventional studies have also demonstrated the beneficial effects of mineralocorticoid receptor antagonists in these disease processes, particularly hypertension, heart failure, and post myocardial infarction, further supporting the role of aldosterone in their pathogenesis. We review the role of aldosterone in these various cardiovascular disease processes along with potential mechanisms and treatment.
Keyword Epithelial sodium-channel
Plasma-renin activity
Resistant hypertension
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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