Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging

Fripp, Jurgen, Bourgeat, Pierrick, Acosta, Oscar, Raniga, Parnesh, Modat, Marc, Pike, Kerryn E., Jones, Gareth, O'Keefe, Graeme, Masters, Colin L., Ames, David, Ellis, Kathryn A., Maruff, Paul, Currie, Jon, Villemagne, Victor L., Rowe, Christopher C., Salvado, Olivier and Ourselin, Sebastien (2008) Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging. Neuroimage, 43 3: 430-439. doi:10.1016/j.neuroimage.2008.07.053


Author Fripp, Jurgen
Bourgeat, Pierrick
Acosta, Oscar
Raniga, Parnesh
Modat, Marc
Pike, Kerryn E.
Jones, Gareth
O'Keefe, Graeme
Masters, Colin L.
Ames, David
Ellis, Kathryn A.
Maruff, Paul
Currie, Jon
Villemagne, Victor L.
Rowe, Christopher C.
Salvado, Olivier
Ourselin, Sebastien
Title Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
Formatted title
Appearance modeling of 11C PiB PET images: Characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2008-11-15
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2008.07.053
Volume 43
Issue 3
Start page 430
End page 439
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
β-amyloid (Aβ) deposition is one of the neuropathological hallmarks of Alzheimer's disease (AD), Aβ burden can be quantified using 11C PiB PET. Neuropathological studies have shown that the initial plaques are located in the temporal and orbitofrontal cortices, extending later to the cingulate, frontal and parietal cortices (Braak and Braak, 1997). Previous studies have shown an overlap in 11C PiB PET retention between AD, mild cognitive impairment (MCI) patients and normal elderly control (NC) participants. It has also been shown that there is a relationship between Aβ deposition and memory impairment in MCI patients.

In this paper we explored the variability seen in 15 AD, 15 MCI and 18 NC by modeling the voxel data from spatially and uptake normalized PiB images using principal component analysis. The first two principal components accounted for 80% of the variability seen in the data, providing a clear separation between AD and NC, and allowing subsequent classification. The MCI cases were distributed along an apparent axis between the AD and NC group, closely aligned with the first principal component axis. The NC cases that were PiB+ formed a distinct cluster that was between, but separated from the AD and PiB- NC clusters. The PiB+ MCI were found to cluster with the AD cases, and exhibited a similar deposition pattern. The primary principal component score was found to correlate with episodic memory scores and mini mental status examination and it was observed that by varying the first principal component, a change in amyloid deposition could be derived that is similar to the expected progression of amyloid deposition observed from post mortem studies.
Keyword 11C PiB PET
Alzheimer's
Mild cognitive impairment
Appearance modeling
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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