beta-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia

Bourgeat, P., Chetelat, G., Villemagne, V. L., Fripp, J., Raniga, P., Pike, K., Acosta, O., Szoeke, C, Ourselin, S, Ames, D., Ellis, K. A., Martins, R. N., Masters, C. L., Rowe, C. C. and Salvado, O. (2010) beta-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology, 74 2: 121-127. doi:10.1212/WNL.0b013e3181c918b5


Author Bourgeat, P.
Chetelat, G.
Villemagne, V. L.
Fripp, J.
Raniga, P.
Pike, K.
Acosta, O.
Szoeke, C
Ourselin, S
Ames, D.
Ellis, K. A.
Martins, R. N.
Masters, C. L.
Rowe, C. C.
Salvado, O.
Title beta-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia
Formatted title
β-Amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia
Journal name Neurology   Check publisher's open access policy
ISSN 0028-3878
1526-632X
Publication date 2010-01
Sub-type Article (original research)
DOI 10.1212/WNL.0b013e3181c918b5
Volume 74
Issue 2
Start page 121
End page 127
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Objective: To investigate whether global and regional β-amyloid (Aβ) burden as measured with 11C Pittsburgh compound B (PIB) PET is associated with hippocampal atrophy characterized using MRI in healthy controls and patients with amnestic mild cognitive impairment (aMCI) or Alzheimer disease (AD).
Methods: Ninety-two elderly healthy controls, 32 subjects with aMCI, and 35 patients with AD were imaged using 11C-PIB PET and MRI. Hippocampal volume was measured and PIB standardized uptake value ratio was extracted after partial volume correction within 41 regions of interest. Global, regional, and voxel-based correlations between PIB and hippocampal volume were computed for each group.
Results: In healthy control participants with elevated neocortex PIB retention, significant correlation was found between PIB retention in the inferior temporal region and hippocampal volume using both region-based and voxel-based approaches. No correlation was found in any other group.
Conclusions: The strong correlation between hippocampal atrophy and β-amyloid (Aβ) burden in the Pittsburgh compound B–positive healthy control group suggests that Aβ deposition in the inferior temporal neocortex is related to hippocampal synaptic and neuronal degeneration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

 
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