Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

Rowe, Christopher C., Ellis, Kathryn A., Rimajova, Miroslava, Bourgeat, Pierrick, Pike, Kerryn E., Jones, Gareth, Fripp, Jurgen, Tochon-Danguy, Henri, Morandeau, Laurence, O'Keefe, Graeme, Price, Roger, Raniga, Parnesh, Robins, Peter, Acosta, Oscar, Lenzo, Nat, Szoeke, Cassandra, Salvado, Olivier, Head, Richard, Martins, Ralph, Masters, Colin L., Ames, David and Villemagne, Victor L. (2010) Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging. Neurobiology of Aging, 31 8: 1275-1283. doi:10.1016/j.neurobiolaging.2010.04.007

Author Rowe, Christopher C.
Ellis, Kathryn A.
Rimajova, Miroslava
Bourgeat, Pierrick
Pike, Kerryn E.
Jones, Gareth
Fripp, Jurgen
Tochon-Danguy, Henri
Morandeau, Laurence
O'Keefe, Graeme
Price, Roger
Raniga, Parnesh
Robins, Peter
Acosta, Oscar
Lenzo, Nat
Szoeke, Cassandra
Salvado, Olivier
Head, Richard
Martins, Ralph
Masters, Colin L.
Ames, David
Villemagne, Victor L.
Title Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 0197-4580
Publication date 2010-08
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2010.04.007
Volume 31
Issue 8
Start page 1275
End page 1283
Total pages 9
Editor Giovanni B. Frisoni
Michael Weiner
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), performed 11C-Pittsburgh Compound B (PiB) scans in 177 healthy controls (HC), 57 mild cognitive impairment (MCI) subjects, and 53 mild Alzheimer's disease (AD) patients. High PiB binding was present in 33% of HC (49% in ApoE-ε4 carriers vs 21% in noncarriers) and increased with age, most strongly in ε4 carriers. 18% of HC aged 60-69 had high PiB binding rising to 65% in those over 80 years. Subjective memory complaint was only associated with elevated PiB binding in ε4 carriers. There was no correlation with cognition in HC or MCI. PiB binding in AD was unrelated to age, hippocampal volume or memory. Beta-amyloid (Aβ) deposition seems almost inevitable with advanced age, amyloid burden is similar at all ages in AD, and secondary factors or downstream events appear to play a more direct role than total beta amyloid burden in hippocampal atrophy and cognitive decline.
Keyword Alzheimer's disease
Mild cognitive impairment
Amyloid imaging
Positron emission tomography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Journal issue: Alzheimer's Disease Neuroimaging Initiative (ADNI) Studies

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