Fgfr3 regulates development of the caudal telencephalon

Moldrich, Randal X., Mezzera, Cecilia, Holmes, William M., Goda, Sailaja, Brookfield, Sam J., Rankin, Alastair J., Barr, Emily, Kurniawan, Nyoman, Dewar, Deborah, Richards, Linda J., López-Bendito, Guillermina and Iwata, Tomoko (2011) Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240 6: 1586-1599. doi:10.1002/dvdy.22636

Author Moldrich, Randal X.
Mezzera, Cecilia
Holmes, William M.
Goda, Sailaja
Brookfield, Sam J.
Rankin, Alastair J.
Barr, Emily
Kurniawan, Nyoman
Dewar, Deborah
Richards, Linda J.
López-Bendito, Guillermina
Iwata, Tomoko
Title Fgfr3 regulates development of the caudal telencephalon
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1058-8388
Publication date 2011-06
Sub-type Article (original research)
DOI 10.1002/dvdy.22636
Volume 240
Issue 6
Start page 1586
End page 1599
Total pages 14
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
The fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostrallow to caudalhigh gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex. Overall, the forebrain structures appeared normal in Fgfr3−/− mice. However, cortical and hippocampal volumes were reduced by 26.7% and 16.3%, respectively. Hypoplasia was particularly evident in the caudo-ventral region of the telencephalon where proliferation was mildly decreased at embryonic day 18.5. Dysplasia of GABAergic neurons in the amygdala and piriform cortex was seen following GAD67 immunohistochemistry. Dye-tracing studies and diffusion magnetic resonance imaging and tractography detected a subtle thalamocortical tract deficit, and significant decreases in the stria terminalis and lateral arms of the anterior commissure. These results indicate the subtle role of Fgfr3 in formation of caudal regions of the telencephalon affecting some brain projections.
Keyword Fgf
Cortical volume
Intermediate progenitor cells
Fibroblast growth-factors
Factor receptor-3
Radial glia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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