Morphine use in cancer surgery

Afsharimani, Banafsheh, Cabot, Peter J. and Parat, Marie-Odile (2011) Morphine use in cancer surgery. Frontiers in Pharmacology, 2 46: 1-8. doi:10.3389/fphar.2011.00046

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Author Afsharimani, Banafsheh
Cabot, Peter J.
Parat, Marie-Odile
Title Morphine use in cancer surgery
Journal name Frontiers in Pharmacology   Check publisher's open access policy
ISSN 1663-9812
Publication date 2011-08-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3389/fphar.2011.00046
Open Access Status DOI
Volume 2
Issue 46
Start page 1
End page 8
Total pages 8
Editor François E. Paris
Olivier Feron
Alex Adjei
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2012
Language eng
Formatted abstract
Morphine is the core of perioperative pain management. However, when it comes to cancer surgery the possibility that this drug might affect tumor recurrence and metastasis has raised concerns. The results of two recent retrospective clinical trials indicated that regional anesthesia/analgesia might be beneficial in prostate and breast cancer surgery. It was proposed that morphine could be responsible for the higher recurrence and mortality rate observed in the general anesthesia/opioid analgesia groups. Nevertheless, the results of several other retrospective studies and one randomized prospective trial failed to confirm any advantage for regional anesthesia/analgesia over general anesthesia and opioid analgesia. Moreover laboratory data on the effect of morphine on cancer are contradictory, ranging from tumor-promoting to anti-tumor effects. Considering that surgical stress and pain promote the recurrence and spread of cancer, choosing a proper analgesic strategy is of high significance. Although the question of whether morphine causes any harm to cancer patients remains unanswered, alternative analgesic regimens could be used concomitant to or instead of morphine to limit its potential adverse effects.
Keyword Morphine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Frontiers in Pharmacology of Anti-Cancer Drugs is a Specialty Section of "Frontiers in Oncology" and "Frontiers in Pharmacology".

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 25 times in Scopus Article | Citations
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Created: Mon, 22 Aug 2011, 15:09:06 EST by Myrtle Sahabandu on behalf of School of Pharmacy