Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers

Popat, Amirali, Hartono, Sandy Budi, Stahr, Frances, Liu, Jian, Qiao, Shi Zhang and Lu, Gao Qing (Max) (2011) Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers. Nanoscale, 3 7: 2801-2818. doi:10.1039/c1nr10224a


Author Popat, Amirali
Hartono, Sandy Budi
Stahr, Frances
Liu, Jian
Qiao, Shi Zhang
Lu, Gao Qing (Max)
Title Mesoporous silica nanoparticles for bioadsorption, enzyme immobilisation, and delivery carriers
Journal name Nanoscale   Check publisher's open access policy
ISSN 2040-3364
2040-3372
Publication date 2011-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/c1nr10224a
Open Access Status Not Open Access
Volume 3
Issue 7
Start page 2801
End page 2818
Total pages 18
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2012
Language eng
Abstract Mesoporous silica nanoparticles (MSNs) provide a non-invasive and biocompatible delivery platform for a broad range of applications in therapeutics, pharmaceuticals and diagnosis. The creation of smart, stimuli-responsive systems that respond to subtle changes in the local cellular environment are likely to yield long term solutions to many of the current drug/gene/DNA/RNA delivery problems. In addition, MSNs have proven to be promising supports for enzyme immobilisation, enabling the enzymes to retain their activity, affording them greater potential for wide applications in biocatalysis and energy. This review provides a comprehensive summary of the advances made in the last decade and a future outlook on possible applications of MSNs as nanocontainers for storage and delivery of biomolecules. We discuss some of the important factors affecting the adsorption and release of biomolecules in MSNs and review of the cytotoxicity aspects of such nanomaterials. The review also highlights some promising work on enzyme immobilisation using mesoporous silica nanoparticles.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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