Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status

Collins, Rachel A., Parsons, Faith, Deverell, Marie, Hollams, Elysia M., Holt, Patrick G. and Sly, Peter D. (2011) Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status. Journal of Allergy and Clinical Immunology, 128 2: 301-307. doi:10.1016/j.jaci.2011.03.016

Author Collins, Rachel A.
Parsons, Faith
Deverell, Marie
Hollams, Elysia M.
Holt, Patrick G.
Sly, Peter D.
Title Risk factors for bronchial hyperresponsiveness in teenagers differ with sex and atopic status
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1016/j.jaci.2011.03.016
Volume 128
Issue 2
Start page 301
End page 307
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Mosby
Collection year 2012
Language eng
Formatted abstract
Sex-related differences in bronchial hyperresponsiveness (BHR) have been reported in adolescents, but the mechanisms remain obscure. 

To investigate the risk factors for BHR in the Raine Study, a community-based longitudinal birth cohort. 

At 14 years of age, children underwent a respiratory assessment including a questionnaire, lung function testing, methacholine challenge, and determination of atopic status. 

A total of 1779 children provided data for assessment, with 1510 completing lung function and methacholine challenge testing. Current asthma was present in 152 (10.4%), 762 (50.5%) were atopic, and 277 (18.6%) had BHR. BHR was more common in girls, whereas atopy was more common in boys, with no sex differences in asthma or current wheeze. Independent risk factors for BHR were being female (odds ratio [OR], 3.45; P < .001), atopy at 14 years (OR, 1.27; P 5 .004), and current asthma (OR, 2.15; P 5 .005). Better lung function was protective against BHR (forced expiratory flow between 25% and 75% of forced vital capacity/forced vital capacity, OR, 0.09; P < .001). Risk factors differed with sex and atopic status. Early-life factors were generally not independent risk factors for BHR at 14 years of age, with the exception of being smaller at birth in boys (birth length, OR, 6 3 1029; P 5 .017) and maternal asthma in girls (OR, 1.84; P 5 .041). Current asthma was not a risk for BHR in nonatopic children.

Bronchial hyperresponsiveness was more common and more severe in girls. These differences could not be explained by differences in lung function or atopic status. 
Keyword Asthma
Longitudinal birth cohort
Lung function
Sex differences
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 17 April 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2012 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 21 Aug 2011, 01:48:50 EST by System User on behalf of Child Health Research Centre