Lymphatic filariasis : A method to identify subclinical lower limb change in PNG adolescents

Gordon, Susan, Melrose, Wayne, Warner, Jeffrey, Buttner, Petra and Ward, Leigh (2011) Lymphatic filariasis : A method to identify subclinical lower limb change in PNG adolescents. PLoS Neglected Tropical Diseases, 5 7: e1242-1-e1242-7. doi:10.1371/journal.pntd.0001242

Author Gordon, Susan
Melrose, Wayne
Warner, Jeffrey
Buttner, Petra
Ward, Leigh
Title Lymphatic filariasis : A method to identify subclinical lower limb change in PNG adolescents
Journal name PLoS Neglected Tropical Diseases   Check publisher's open access policy
ISSN 1935-2727
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1371/journal.pntd.0001242
Open Access Status DOI
Volume 5
Issue 7
Start page e1242-1
End page e1242-7
Total pages 8
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2012
Language eng
Formatted abstract
Lymphedema related to lymphatic filariasis (LF) is a disabling condition that commonly manifests in adolescence. Fifty-three adolescents, 25 LF infected and 28 LF non-infected, in age and sex-matched groups, using the Binax ICT rapid card test for filarial antigen were recruited to the study. None of the participants had overt signs of lymphedema. Lymphedema assessment measures were used to assess lower limb tissue compressibility (tonometry), limb circumference (tape measure), intra- and extra-cellular fluid distribution (bioimpedance) and joint range of motion (goniometry). The mean tonometric measurements from the left, right, and dominant posterior thighs were significantly larger in participants with LF compared to participants who had tested negative for LF (p = 0.005, p = 0.004, and p = 0.003, respectively) indicating increased tissue compressibility in those adolescents with LF. ROC curve analysis to define optimal cut-off of the tonometry measurements indicated that at 3.5, sensitivity of this potential screening test is 100% (95%-CI = 86.3%, 100%) and specificity is 21.4% (95%-CI = 8.3%, 41.0%). It is proposed that this cut-off can be used to indicate tissue change characteristic of LF in an at-risk population of PNG adolescents. Further longitudinal research is required to establish if all those with tissue change subsequently develop lymphedema. However, thigh tonometry to identify early tissue change in LF positive adolescents may enable early intervention to minimize progression of lymphedema and prioritization of limited resources to those at greatest risk of developing lifetime morbidity.
Keyword Brugia-Malayi Infection
Global Program
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 21 Aug 2011, 01:36:33 EST by System User on behalf of School of Chemistry & Molecular Biosciences