Lateral genetic transfer and the construction of genetic exchange communities

Skippington, Elizabeth and Ragan, Mark A. (2011) Lateral genetic transfer and the construction of genetic exchange communities. Fems Microbiology Reviews, 35 5: 707-735. doi:10.1111/j.1574-6976.2010.00261.x


Author Skippington, Elizabeth
Ragan, Mark A.
Title Lateral genetic transfer and the construction of genetic exchange communities
Journal name Fems Microbiology Reviews   Check publisher's open access policy
ISSN 0168-6445
1574-6976
Publication date 2011-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1574-6976.2010.00261.x
Volume 35
Issue 5
Start page 707
End page 735
Total pages 29
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Lateral genetic transfer (LGT) is a major source of phenotypic innovation among
bacteria. Determinants for antibiotic resistance and other adaptive traits can spread rapidly, particularly by conjugative plasmids, but also phages and natural transformation. Each successive step from the uptake of foreign DNA, its genetic recombination and regulatory integration, to its establishment in the host population presents differential barriers and opportunities. The emergence of successive multidrug-resistant strains of Staphylococcus aureus illustrates the ongoing role of LGT in the combinatorial assembly of pathogens. The dynamic interplay among hosts, vectors, DNA elements, combinations of genetic determinants and environments constructs communities of genetic exchange. These relations can be abstracted as a graph, within which an exchange community might correspond to a path, transitively closed set, clique or near-clique. We provide a set-based definition, and review the features of actual genetic exchange communities (GECs), adopting first a knowledge-driven approach based on literature, and then a synoptic data-centric bioinformatic approach. GECs are diverse, but share some common features.
Keyword Antibiotic resistance
Lateral genetic transfer
Horizontal genetic transfer
Genetic exchange communities
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: Antibiotic Resistance

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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