Theoretical models of neural circuit development

Simpson, Hugh D., Mortimer, Duncan and Goodhill, Geoffrey J. (2009) Theoretical models of neural circuit development. Current Topics in Developmental Biology, 87 1-51. doi:10.1016/S0070-2153(09)01201-0


Author Simpson, Hugh D.
Mortimer, Duncan
Goodhill, Geoffrey J.
Title Theoretical models of neural circuit development
Journal name Current Topics in Developmental Biology   Check publisher's open access policy
ISSN 0070-2153
1557-8933
ISBN 9780123744692
0123744695
Publication date 2009-05-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0070-2153(09)01201-0
Volume 87
Start page 1
End page 51
Total pages 51
Editor Oliver Hobert
Place of publication Maryland Heights, MO, U.S.A.
Publisher Academic Press
Language eng
Formatted abstract
Proper wiring up of the nervous system is critical to the development of organisms capable of complex and adaptable behaviors. Besides the many experimental advances in determining the cellular and molecular machinery that carries out this remarkable task precisely and robustly, theoretical approaches have also proven to be useful tools in analyzing this machinery. A quantitative understanding of these processes can allow us to make predictions, test hypotheses, and appraise established concepts in a new light. Three areas that have been fruitful in this regard are axon guidance, retinotectal mapping, and activity‚Äźdependent development. This chapter reviews some of the contributions made by mathematical modeling in these areas, illustrated by important examples of models in each section. For axon guidance, we discuss models of how growth cones respond to their environment, and how this environment can place constraints on growth cone behavior. Retinotectal mapping looks at computational models for how topography can be generated in populations of neurons based on molecular gradients and other mechanisms such as competition. In activity‚Äźdependent development, we discuss theoretical approaches largely based on Hebbian synaptic plasticity rules, and how they can generate maps in the visual cortex very similar to those seen in vivo. We show how theoretical approaches have substantially contributed to the advancement of developmental neuroscience, and discuss future directions for mathematical modeling in the field.
Keyword Primary visual-cortex
Timing-dependent plasticity
Basic network principles
Receptive-field properties
Optic-nerve regeneration
Half retinal projection
Transient up-regulation
Retinotectal projection
Axon guidance
Molecular gradients
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Special Issue: "Development of Neural Circuitry" Published as Chapter 1.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Mathematics and Physics
Queensland Brain Institute Publications
ERA 2012 Admin Only
 
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