Locked nucleic acid oligonucleotides towards clinical applications

Veedu, Rakesh N. and Wengel, Jesper (2011). Locked nucleic acid oligonucleotides towards clinical applications. In Li-He Zhang, Zhen Xi and Jyoti Chattopadhyaya (Ed.), Medicinal Chemistry of Nucleic Acids (pp. 355-348) New Jersey, U.S.A: John Wiley & Sons.

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Author Veedu, Rakesh N.
Wengel, Jesper
Title of chapter Locked nucleic acid oligonucleotides towards clinical applications
Title of book Medicinal Chemistry of Nucleic Acids
Place of Publication New Jersey, U.S.A
Publisher John Wiley & Sons
Publication Year 2011
Sub-type Research book chapter (original research)
ISBN 9780470596685
Editor Li-He Zhang
Zhen Xi
Jyoti Chattopadhyaya
Chapter number 9
Start page 355
End page 348
Total pages 94
Total chapters 12
Collection year 2012
Language eng
Abstract/Summary Nucleic acid–based therapeutic technologies (Figure 9.1) have significantly advanced in the past two decades toward the treatment of many diseases. The first such drug to enter clinic was vitravene®, an antisense oligonucleotide for the treatment of cytomegalovirus retinitis [1]. Later, research on aptamers led to the marketing of macugen®, an inhibitor of vascular endothelial growth factor (VEGF) for the treatment of age related macular degeneration (AMD) [2]. Nucleic acid–based therapeutic approaches mainly include antisense [3,4], ribozymes [4], small interfering RNA (siRNA) [4–6], microRNA (miRNA) [7–10] targeting and aptamers [11–15]. Oligonucleotides composed of naturally occurring DNA or RNA nucleotides pose some limitations because of their poor RNA binding affinity, low degree of nuclease resistance, and low bioavilability. To overcome these limitations, chemically modified nucleic acids have been introduced, among which locked nucleic acid (LNA) [16–20] proved to be unique and is now used extensively for various applications in chemical biology [21–23].
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Thu, 18 Aug 2011, 13:47:57 EST by Dr Rakesh Naduvile Veedu on behalf of School of Chemistry & Molecular Biosciences