Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers

Veedu, Rakesh N. and Wengel, Jesper (2009) Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers. Molecular BioSystems, 5 8: 787-792. doi:10.1039/b905513b


Author Veedu, Rakesh N.
Wengel, Jesper
Title Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers
Journal name Molecular BioSystems   Check publisher's open access policy
ISSN 1742-206X
1742-2051
Publication date 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/b905513b
Open Access Status Not Open Access
Volume 5
Issue 8
Start page 787
End page 792
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract Among numerous nucleic acid analogs reported in the past decades, locked nucleic acid (LNA) has received substantial attention and has become a significant tool within chemical biology disciplines like molecular biology research, diagnostics and therapeutic development. However, despite their obvious structurally unique properties, LNA-based aptamers for diagnostic and therapeutic applications remain largely unexplored. Future evolution of LNA oligonucleotide aptamers will depend on scientific breakthroughs relating to enzymatic polymerization using LNA nucleoside triphosphates as substrates. Herein, we highlight recent developments in this direction using various polymerases.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 18 Aug 2011, 12:20:08 EST by Dr Rakesh Naduvile Veedu on behalf of School of Chemistry & Molecular Biosciences