Merkel cell polyoma virus in lung cancer

Relan, V., Bowman, R. V., Yang, I. A. and Fong, K. M. (2011). Merkel cell polyoma virus in lung cancer. In: Supplement to Journal of Thoracic Oncology: 3rd Australian Lung Cancer Conference (ALCC). 3rd Australian Lung Cancer Conference (ALCC), Melbourne VIC, Australia, (S36-S36). 6-8 October 2011. doi:10.1097/01.JTO.0000394634.73009.dc

Author Relan, V.
Bowman, R. V.
Yang, I. A.
Fong, K. M.
Title of paper Merkel cell polyoma virus in lung cancer
Conference name 3rd Australian Lung Cancer Conference (ALCC)
Conference location Melbourne VIC, Australia
Conference dates 6-8 October 2011
Proceedings title Supplement to Journal of Thoracic Oncology: 3rd Australian Lung Cancer Conference (ALCC)   Check publisher's open access policy
Journal name Journal of Thoracic Oncology   Check publisher's open access policy
Place of Publication Philadelphia PA, United States
Publisher Lippincott Willams & Wilkins
Publication Year 2011
Sub-type Published abstract
DOI 10.1097/01.JTO.0000394634.73009.dc
Open Access Status
ISSN 1556-0864
Volume 6
Issue 3, Supp. 1
Start page S36
End page S36
Total pages 1
Collection year 2012
Language eng
Formatted Abstract/Summary
Polyoma Virus refers to viruses, which have ability to produce multiple (poly) tumours (oms). They are potentially oncogenic (tumour-causing); they often persist as latent infections in a host without causing disease, but may produce tumours in a host of a different species, or a host with an ineffective immune system. WU (Washington University) virus and KI (Karolinska Institute) virus are novel virus identified in respiratory secretions in acute respiratory infections. MC (Merkel cell polyoma virus) virus was discovered in 2008 in Merkel cell carcinoma (MCC). MCC is a rare aggressive small cell neuroendocrine carcinoma primarily derived from the skin, morphologically indistinguishable from small cell lung carcinoma (SCLC). The study aimed to detect a relationship between lung cancer and MC polyoma virus.

Methods: High molecular weight genomic DNA from the tissue was isolated using standard salt extraction method. All DNAs were quantified. Diagnostic stringency was maintained for this study. We screened 231 lung cancer subjects for Merkel cell polyoma virus using real time PCR.

Results: One out of 231 lung cancer subjects (1/231) found to be positive for Merkel cell polyoma virus. Sequencing is underway.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published under Poster Abstracts: 3rd Australian Lung Cancer Conference (ALCC).

Document type: Conference Paper
Collection: School of Medicine Publications
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Created: Tue, 16 Aug 2011, 13:18:58 EST by Mr Stephen Woods on behalf of School of Medicine