Epstein–Barr virus and multiple sclerosis

Lucas, R. M., Hughes, A. M., Lay, M-L. J., Ponsonby, A-L., Dwyer, D. E., Taylor, B. V. and Pender, M. P. (2011) Epstein–Barr virus and multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 82 10: 1142-1148. doi:10.1136/jnnp-2011-300174

Author Lucas, R. M.
Hughes, A. M.
Lay, M-L. J.
Ponsonby, A-L.
Dwyer, D. E.
Taylor, B. V.
Pender, M. P.
Title Epstein–Barr virus and multiple sclerosis
Journal name Journal of Neurology, Neurosurgery and Psychiatry   Check publisher's open access policy
ISSN 0022-3050
Publication date 2011-08-11
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1136/jnnp-2011-300174
Volume 82
Issue 10
Start page 1142
End page 1148
Total pages 7
Place of publication London, United Kingdom
Publisher B M J Group
Collection year 2012
Language eng
Abstract This review of the considerable evidence linking Epstein–Barr virus (EBV) infection to risk and disease progression in multiple sclerosis (MS) builds on the background to the virus and its interactions with the human host available in the online supplement (see supplement, available online only). The evidence for a similarity in the geographic patterns of occurrence of MS and EBV infection (with infectious mononucleosis or EBV specific serology used as surrogate markers), when reviewed critically, is very limited. There is strong evidence however that people with MS are more likely to report a past history of infectious mononucleosis (thought to represent initial EBV infection at an older age), and higher titres of EBV specific antibodies are associated with an increased risk of developing MS. Elevated levels of the latter are apparent many years before MS onset (compared with non-MS controls) and there is a dose–response relationship between MS risk and antibody titre, with antibodies to the EBV nuclear antigen-1 particularly important. The evidence in relation to EBV DNA load in blood or CSF is conflicting, as is that in relation to T cell responses to EBV. Several hypotheses that have been proposed to explain the links between EBV and MS risk are reviewed and gaps requiring further research are identified.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes JNNP Online First, published on August 11, 2011

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 37 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 47 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 15 Aug 2011, 14:43:16 EST by Matthew Lamb on behalf of School of Medicine