Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke

Singh, P., Yan, J., Hull, R., Read, S., O'Sullivan, J., Henderson, R.D., Rose, S., Greer, J.M. and McCombe, P.A. (2011) Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke. Journal of the Neurological Sciences, 304 1-2: 117-121. doi:10.1016/j.jns.2011.01.025

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Author Singh, P.
Yan, J.
Hull, R.
Read, S.
O'Sullivan, J.
Henderson, R.D.
Rose, S.
Greer, J.M.
McCombe, P.A.
Title Levels of phosphorylated axonal neurofilament subunit H (pNfH) are increased in acute ischemic stroke
Journal name Journal of the Neurological Sciences   Check publisher's open access policy
ISSN 0022-510X
1878-5883
Publication date 2011-05
Sub-type Article (original research)
DOI 10.1016/j.jns.2011.01.025
Volume 304
Issue 1-2
Start page 117
End page 121
Total pages 5
Place of publication Amsterdam, The Netherlands
Publisher Elsevier
Collection year 2012
Language eng
Abstract For the study of stroke outcomes, there is the need for measurements of severity of stroke damage. Phosphorylated neurofilament heavy protein (pNfH) levels are elevated in axonal injury. We have measured levels of pNfH in stroke and correlated these levels with measures of stroke severity. Blood samples were collected from 54 ischaemic stroke patients at day 1, week 1 (days 7–10) and weeks 3–6, and an ELISA was used to measure pNfH levels in each patient at each time-point. Serum pNfH levels were significantly elevated in stroke patients compared to healthy controls. The levels were low at day 1, higher at day 7 and reached a peak at week 3, the latest day that we assessed. Significant associations were found between the pNfH levels at week 3 and early and stroke severity, size and outcome. Blood pNfH levels that reflect the severity of ischaemic stroke, are correlated with outcome and rise during the weeks after stroke. This may be a useful measure of tissue damage in stroke.
Keyword Acute ischemic stroke
Neurofilament
Axonal injury
Biomarker
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Mon, 15 Aug 2011, 08:58:01 EST by Matthew Lamb on behalf of School of Medicine