William Gowers' interpretation of epileptogenic mechanisms: 1880-1906

Eadie, Mervyn J. (2011) William Gowers' interpretation of epileptogenic mechanisms: 1880-1906. Epilepsia, 52 6: 1045-1051.


Author Eadie, Mervyn J.
Title William Gowers' interpretation of epileptogenic mechanisms: 1880-1906
Journal name Epilepsia   Check publisher's open access policy
ISSN 0013-9580
1528-1167
Publication date 2011-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1528-1167.2011.02983.x
Volume 52
Issue 6
Start page 1045
End page 1051
Total pages 7
Place of publication Hoboken, NJ, U.S.A.
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract In the 1870s, early in his neurologic career, William Gowers (1845–1911) was exposed to three main schools of thought concerning epileptogenesis, namely, that seizures resulted from (1) excessive neural activity in the medulla oblongata or pons (Marshall Hall, John Russell Reynolds, and Brown-Séquard), (2) excessive local cerebral cortical activity (Hughlings Jackson), or (3) suddenly decreased cerebral activity that released the intrinsic contractibility of skeletal muscle (Radcliffe). By 1881, Gowers had reasoned his way to the idea that epileptogenesis was best accounted for by local cortical overactivity. This overactivity might at times be initiated by local loss of inhibition. The overactivity in turn then might inhibit other parts of the central nervous system to explain loss of consciousness in seizures and postseizure temporary hemiparesis. The possibilities of the idea of inhibition, at first often called “resistance,” continued to interest Gowers over the following 25 years. He settled on the synaptic gap as its likely site. However, the inhibition mechanism that he proposed, namely, retraction of dendrites, was rather extraordinary in the light of subsequent knowledge.
Keyword Epileptogenesis
Gowers
Inhibition
Jackson
Resistance
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
 
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