A novel DNA-based nanostructure for single molecule detection purposes

Rahaie, Mahdi, Naghavi, Mohammad R., Alizadeh, Houshang, Malboobi, Mohammad A. and Dimitrov, Krassen (2011) A novel DNA-based nanostructure for single molecule detection purposes. International Journal of Nanotechnology, 8 6-7: 458-470. doi:10.1504/IJNT.2011.040188

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Author Rahaie, Mahdi
Naghavi, Mohammad R.
Alizadeh, Houshang
Malboobi, Mohammad A.
Dimitrov, Krassen
Title A novel DNA-based nanostructure for single molecule detection purposes
Journal name International Journal of Nanotechnology   Check publisher's open access policy
ISSN 1475-7435
Publication date 2011
Sub-type Article (original research)
DOI 10.1504/IJNT.2011.040188
Volume 8
Issue 6-7
Start page 458
End page 470
Total pages 13
Place of publication Olney, Bucks, U.K.
Publisher Inderscience Publishers
Collection year 2012
Language eng
Formatted abstract
Recently, interest in DNA nanoparticle hybrid structures synthesis for developing nanoscale assemblies with innovative diagnostics, optical and magnetic properties, all combined in one single nanostructure, is increasing. In other words, nanostructures, which show fluorescent and magnetic features simultaneously, are of particular interest for diagnostics objectives, especially genetic research applications. In this work, we report the synthesis of a magnetic fluorescent DNA-based dumbbell nanostructure with different size nanoparticles. The DNA dumbbell was made by combining a number of biological tools such as filling, digestion and protein ligand interaction and visualised by fluorescence microscopy after molecular combing, then proved by AFM using tapping mode. The method described herein provides a new tool and view for making and designing controlled DNA-based nanostructure, which offers more perspectives in the nanomanipulation of single molecules for diagnostics purposes, such as creating barcode labels.
Keyword DNA-based nanostructure
Atomic force microscopy
Fluorescent microscopy
Single molecule detection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
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Created: Sun, 14 Aug 2011, 00:56:36 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology