Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding

Dantas de Araujo, Aline, Callaghan, Brid, Nevin, Simon T., Daly, Norelle L., Craik, David J., Moretta, Melissa, Hopping, Gene, Christie, Macdonald J., Adams, David J. and Alewood, Paul F. (2011) Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Edition), 50 29: 6527-6529. doi:10.1002/anie.201101642


Author Dantas de Araujo, Aline
Callaghan, Brid
Nevin, Simon T.
Daly, Norelle L.
Craik, David J.
Moretta, Melissa
Hopping, Gene
Christie, Macdonald J.
Adams, David J.
Alewood, Paul F.
Title Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding
Journal name Angewandte Chemie (International Edition)   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2011-07-11
Sub-type Article (original research)
DOI 10.1002/anie.201101642
Volume 50
Issue 29
Start page 6527
End page 6529
Total pages 3
Place of publication Weinheim, Germany
Publisher Wiley - VCH Verlag
Collection year 2012
Language eng
Formatted abstract
Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously “unfoldable” miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.
Keyword Disulfides
Ion channels
Peptides
Regioselective folding
Selenocysteine
Gated sodium-channels
Receptor antagonists
Diselenide bridges
Potent
Analogs
Peptides
Pain
Replacement
Chemistry
Proteins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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