Clinical review: Ketones and brain injury

White, Hayden and Venkatesh, Balasubramanian (2011) Clinical review: Ketones and brain injury. Critical Care, 15 2: 1-10. doi:10.1186/cc10020

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Author White, Hayden
Venkatesh, Balasubramanian
Title Clinical review: Ketones and brain injury
Journal name Critical Care   Check publisher's open access policy
ISSN 1466-609X
Publication date 2011-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/cc10020
Open Access Status File (Publisher version)
Volume 15
Issue 2
Start page 1
End page 10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2012
Language eng
Abstract Although much feared by clinicians, the ability to produce ketones has allowed humans to withstand prolonged periods of starvation. At such times, ketones can supply up to 50% of basal energy requirements. More interesting, however, is the fact that ketones can provide as much as 70% of the brain's energy needs, more efficiently than glucose. Studies suggest that during times of acute brain injury, cerebral uptake of ketones increases significantly. Researchers have thus attempted to attenuate the effects of cerebral injury by administering ketones exogenously. Hypertonic saline is commonly utilized for management of intracranial hypertension following cerebral injury. A solution containing both hypertonic saline and ketones may prove ideal for managing the dual problems of refractory intracranial hypertension and low cerebral energy levels. The purpose of the present review is to explore the physiology of ketone body utilization by the brain in health and in a variety of neurological conditions, and to discuss the potential for ketone supplementation as a therapeutic option in traumatic brain injury.
Keyword D-beta-hydroxybutyrate
Nicotinamide-adenine dinucleotide
Function improving agent
Short-term starvation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
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Created: Sun, 14 Aug 2011, 00:25:09 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH