Bioactive cystine knot proteins

Daly, Norelle L. and Craik, David J. (2011) Bioactive cystine knot proteins. Current Opinion in Chemical Biology, 15 3: 362-368. doi:10.1016/j.cbpa.2011.02.008

Author Daly, Norelle L.
Craik, David J.
Title Bioactive cystine knot proteins
Journal name Current Opinion in Chemical Biology   Check publisher's open access policy
ISSN 1367-5931
Publication date 2011-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cbpa.2011.02.008
Volume 15
Issue 3
Start page 362
End page 368
Total pages 7
Place of publication London, Engalnd, U.K.
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
The cystine knot is a structural motif that confers exceptional stability on proteins. Here we provide an update on the topology of the cystine knot and the combinatorial diversity of proteins that contain it. We describe recent chemical biology studies that have utilised this structural motif for the development of potential therapeutic or diagnostic agents. The cystine knot appears to have evolved in fungi, plants and animals as a stable and adaptable framework for the display of a wide variety of bioactive peptide sequences, but is amenable to chemical or recombinant synthesis and thus has a wide range of applications in chemistry, biology and medicine.
Keyword Kappa-Conotoxin Pviia
Drug Design
Circular Proteins
Structural Motif
Macrocyclic Peptides
Integrin Expression
Plant Cyclotides
Living Subjects
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 54 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 59 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 14 Aug 2011, 00:23:16 EST by System User on behalf of Institute for Molecular Bioscience