Acute nicotine enhances strategy-based semantic processing in Parkinson's disease

Holmes, Anna D., Copland, David A., Silburn, Peter A. and Chenery, Helen J. (2011) Acute nicotine enhances strategy-based semantic processing in Parkinson's disease. International Journal of Neuropsychopharmacology, 14 7: 877-885. doi:10.1017/S1461145710001665


Author Holmes, Anna D.
Copland, David A.
Silburn, Peter A.
Chenery, Helen J.
Title Acute nicotine enhances strategy-based semantic processing in Parkinson's disease
Journal name International Journal of Neuropsychopharmacology   Check publisher's open access policy
ISSN 1461-1457
1469-5111
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1017/S1461145710001665
Open Access Status DOI
Volume 14
Issue 7
Start page 877
End page 885
Total pages 9
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2012
Language eng
Formatted abstract
Nicotinic mechanisms may play a role in the cognitive deficits of Parkinson's disease (PD). Recently, on a cognitively demanding strategy-based priming task, nicotine selectively affected controlled semantic processing in young adult non-smokers as reported by Holmes et al. (International Journal of Neuropsychopharmacology 11, 389-399, 2008). Such controlled semantic processing is compromised in PD. This study investigated the effects of acute transdermal nicotine on controlled semantic processing in non-smokers with PD (n=10) and non-smoking matched controls (n=16) using a strategy-based semantic priming paradigm. Transdermal nicotine patches (7 mg/24 h) were administered in a double-blind, placebo-controlled, crossover design. Participants were instructed to expect target words from specified semantic categories based on the primes, while unexpected targets were also presented. Priming conditions included those concurring with trained expectations (expected-related and expected-unrelated), those which did not (unexpected-related and unexpected-unrelated), and neutral-baseline conditions. Controls evidenced significant expectancy effects (i.e. reaction-time differences for expected vs. unexpected conditions) under both drug states. An expectancy effect was not evident for PD under placebo due to a lack of reaction-time slowing for unexpected conditions. However, under nicotine an expectancy effect was present for PD at a level comparable to controls. Overall the findings indicate that nicotine can improve impaired controlled semantic processing in PD possibly via enhanced expectancy or inhibitory mechanisms.
Keyword Controlled processing
Expectancy
Nicotine
Parkinson's disease
Semantic priming
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Health and Rehabilitation Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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