Porphyrin containing isoindoline nitroxides as potential fluorescence sensors of free radicals

Yan, Guo-Ping, Fairfull-Smith, Kathryn E., Smith, Craig D., Hanson, Graeme R. and Bottle, Steven E. (2011) Porphyrin containing isoindoline nitroxides as potential fluorescence sensors of free radicals. Journal of Porphyrins and Phthalocyanines, 15 4: 230-239. doi:10.1142/S1088424611003203


Author Yan, Guo-Ping
Fairfull-Smith, Kathryn E.
Smith, Craig D.
Hanson, Graeme R.
Bottle, Steven E.
Title Porphyrin containing isoindoline nitroxides as potential fluorescence sensors of free radicals
Journal name Journal of Porphyrins and Phthalocyanines   Check publisher's open access policy
ISSN 1088-4246
1099-1409
Publication date 2011-04
Sub-type Article (original research)
DOI 10.1142/S1088424611003203
Volume 15
Issue 4
Start page 230
End page 239
Total pages 10
Place of publication Singapore, Singapore
Publisher World Scientific Publishing
Collection year 2012
Language eng
Abstract A series of new spin-labeled porphyrin containing isoindoline nitroxide moieties were synthesized and characterized as potential free radical fluorescence sensors. Fluorescence-suppression was observed in the free-base monoradical porphyrins, whilst the free-base biradical porphyrins exhibited highly suppressed fluorescence about three times greater than the monoradical porphyrins. The observed fluorescence-suppression was attributed to enhanced intersystem crossing resulting from electronexchange between the doublet nitroxide and the excited porphyrin fluorophore. Notably, fluorescencesuppression was not as strong in the related metalated porphyrins, possibly due to insufficient spin coupling between the nitroxide and the porphyrin. Continuous wave EPR spectroscopy of the diradical porphyrins in fluid solution suggests that the nitroxyl-nitroxyl interspin distance is long enough and tumbling is fast enough not to detect dipolar coupling.
Keyword Porphyrins
Nitroxides
Fuorescence
Radicals
Profluorescent probes
Spin probes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Centre for Advanced Imaging Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 14 Aug 2011, 00:07:47 EST by System User on behalf of Centre for Advanced Imaging