Osteoarthritis Modular Measurement System (O2MS): Validity and responsiveness of Module 4 (Patient Global Assessment)

Bellamy, Nicholas, Hendrikz, Joan and Wilson, C. (2011). Osteoarthritis Modular Measurement System (O2MS): Validity and responsiveness of Module 4 (Patient Global Assessment). In: Tore K. Kvien, EULAR 2011, London, U.K., (391-391). 25-28 May 2011.

Author Bellamy, Nicholas
Hendrikz, Joan
Wilson, C.
Title of paper Osteoarthritis Modular Measurement System (O2MS): Validity and responsiveness of Module 4 (Patient Global Assessment)
Formatted title
Osteoarthritis Modular Measurement System (O2MS): Validity and responsiveness of Module 4 (Patient Global Assessment)
Conference name EULAR 2011
Conference location London, U.K.
Conference dates 25-28 May 2011
Convener EULAR: The European League Against Rheumatism
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
Place of Publication London, U.K.
Publisher BMJ Group
Publication Year 2011
Year available 2010
Sub-type Published abstract
ISSN 0003-4967
1468-2060
Editor Tore K. Kvien
Volume 70
Issue Supp. 3
Start page 391
End page 391
Total pages 1
Collection year 2011
Language eng
Formatted Abstract/Summary
Background: The Osteoarthritis Modular Measurement System (O2MS™) contains 10 modules, of which Module 4 concerns Patient Global Assessment (PGA). There is currently no international agreement of the wording of the PGA question or a uniform response scale. However, PGA questioning is a key element of the OMERACT-OARSI Responder Criteria. Based on previous work conducted using the WOMBAT™ Index and the Osteoarthritis Global Index (OGI™), a battery of PGA questions was elaborated and incorporated as Module 4 of a multidimensional Patient Reported Outcome Measure (PRO) for OA clinical trials termed O2MS™.

Objectives: The purpose of this study was to examine the validity and responsiveness of O2MS™ Module 4 (Patient Global Assessment).

Methods: During the validation of a mobile phone-based version of the WOMAC® Index, 52 patients with hip and knee osteoarthritis (OA), about to undergo total joint replacement surgery completed the O2MS™ (Module 4) pre-operatively and ∼12 weeks post-operatively. The study population was as follows (32 Females and 20 males, 18 hip OA and 34 Knee OA, Mean Age =68 (range 47-85), Mean disease duration 9.4 yrs (range 0.83 – 30 yrs).

Results: Mean (SD) WOMAC® NRS3.1 Index scores pre-op for the pain, stiffness and function subscales were as follows: Pain NRS =5.2 (2.00); Stiffness NRS =5.5 (2.21); Function NRS =5.6 (2.18). Median (Inter-quartile range) O2MS™ Module 4 scores pre-op were as follows: PGA pain =6 (4-8); PGA Stiffness =6 (4-8); PGA function =7 (5-8). Pearson correlations between O2MS™ and WOMAC® scores pre-op were as follows: Pain =0.75; Stiffness =0.81; Function =0.84. For each subscale, the pattern of partial correlations between the WOMAC® and O2MS™ scores, controlling for the other two WOMAC® subscales, supported the construct validity of the O2MS™ subscales. Responsiveness to intervention was assessed by comparing the O2MS™ scores post-operatively with those preoperatively. Statistically significant improvements in scores post-operatively were detected using Wilcoxon signed ranks test for matched pairs (all p<0.0001).

Conclusions: These data are supportive of the validity and responsiveness of O2MS™ (Module 4), and together with the demonstrable feasibility of asking short global assessment questions, are aligned with OMERACT Filter Criteria for Truth, Discrimination and Feasibility.
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Conference Paper
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Created: Thu, 11 Aug 2011, 14:24:53 EST by Chesne McGrath on behalf of Medicine - Royal Brisbane and Women's Hospital