Origin and diversification of the human parasite Schistosoma mansoni

Morgan, Jess A. T., Dejong, Randall J., Adeoye, Grace O., Ansa, Ebenezer D. O., Barbosa, Constanca S., Bremond, Phillippe, Cesari, Italo M., Charbonnel, Nathalie, Correa, Lygia R., Coulibaly, Godefroy, D'Andrea, Paul Sergio, De Souza, Cecilia Pereira, Doenhoff, Michael J., File, Sharon, Idris, Mohamed A., Incani, R. Nino, Jarne, Philippe, Karanja, Diana M. S., Kazibwe, Francis, Kpikpi, John, Lwambo, Nicholas J. S., Mabaye, Amadou, Magalhaes, Luiz A., Makundi, Asanteli, Mone, Helene, Mouahid, Gabriel, Muchemi, Gerald M., Mungai, Ben N., Sene, Mariama, Southgate, Vaughan, Tchuente, Louis Albert Tchuem, Theron, Andre, Yousif, Fouad, Zanotti-Magalhaes, Eliana M,, Mkoji, Gerald M. and Loker, Eric S. (2005) Origin and diversification of the human parasite Schistosoma mansoni. Molecular Ecology, 14 12: 3889-3902. doi:10.1111/j.1365-294X.2005.02709.x

Author Morgan, Jess A. T.
Dejong, Randall J.
Adeoye, Grace O.
Ansa, Ebenezer D. O.
Barbosa, Constanca S.
Bremond, Phillippe
Cesari, Italo M.
Charbonnel, Nathalie
Correa, Lygia R.
Coulibaly, Godefroy
D'Andrea, Paul Sergio
De Souza, Cecilia Pereira
Doenhoff, Michael J.
File, Sharon
Idris, Mohamed A.
Incani, R. Nino
Jarne, Philippe
Karanja, Diana M. S.
Kazibwe, Francis
Kpikpi, John
Lwambo, Nicholas J. S.
Mabaye, Amadou
Magalhaes, Luiz A.
Makundi, Asanteli
Mone, Helene
Mouahid, Gabriel
Muchemi, Gerald M.
Mungai, Ben N.
Sene, Mariama
Southgate, Vaughan
Tchuente, Louis Albert Tchuem
Theron, Andre
Yousif, Fouad
Zanotti-Magalhaes, Eliana M,
Mkoji, Gerald M.
Loker, Eric S.
Title Origin and diversification of the human parasite Schistosoma mansoni
Journal name Molecular Ecology   Check publisher's open access policy
ISSN 0962-1083
Publication date 2005-10
Sub-type Article (original research)
DOI 10.1111/j.1365-294X.2005.02709.x
Volume 14
Issue 12
Start page 3889
End page 3902
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Schistosoma mansoni is the most widespread of the human- infecting schistosomes, present in 54 countries, predominantly in Africa, but also in Madagascar, the Arabian Peninsula, and the Neotropics. Adult-stage parasites that infect humans are also occasionally recovered from baboons, rodents, and other mammals. Larval stages of the parasite are dependent upon certain species of freshwater snails in the genus Biomphalaria , which largely determine the parasite’s geographical range. How S. mansoni genetic diversity is distributed geographically and among isolates using different hosts has never been examined with DNA sequence data. Here we describe the global phylogeography of S. mansoni using more than 2500 bp of mitochondrial DNA (mtDNA) from 143 parasites collected in 53 geographically widespread localities. Considerable within-species mtDNA diversity was found, with 85 unique haplotypes grouping into five distinct lineages. Geographical separation, and not host use, appears to be the most important factor in the diversification of the parasite. East African specimens showed a remarkable amount of variation, comprising three clades and basal members of a fourth, strongly suggesting an East African origin for the parasite 0.30–0.43 million years ago, a time frame that follows the arrival of its snail host. Less but still substantial variation was found in the rest of Africa. A recent colonization of the New World is supported by finding only seven closely related New World haplotypes which have West African affinities. All Brazilian isolates have nearly identical mtDNA haplotypes, suggesting a founder effect from the establishment and spread of the parasite in this large country.
Keyword Africa
Slave trade
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Agriculture and Food Sciences
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